Vitamin D in Pediatric Asthma: a Randomized Controlled Open-label Pilot Trial
Status:
Unknown status
Trial end date:
2016-01-01
Target enrollment:
Participant gender:
Summary
This is a pilot randomized controlled trial of lower vs. higher dose vitamin D
supplementation in D-deficient asthmatic children, to determine necessary sample sizes for
outcome measures in a larger multisite study, and to examine possible relationships and
effect sizes between various biological markers that may be important to the pathophysiology
of childhood asthma.
Aims of the study are to:
1. Evaluate effect sizes for relationships between serum 25OH-vitD and omega-fatty acid
(FA) biomarkers, before and after supplementation with lower or higher dose vitamin D,
on immune function, and asthma severity.
2. Characterize changes in innate and adaptive immune function and inflammatory responses
in asthmatic D-deficient youth at baseline and after vitD supplements, by dietary
O6:O3FA status and vitD dose.
Phase:
N/A
Details
Lead Sponsor:
Nationwide Children's Hospital
Collaborator:
Ohio State University
Treatments:
Cholecalciferol Ergocalciferols Vitamin D Vitamins