Vitamin E for Oxaliplatin-induced Peripheral Neuropathy Prophylaxis
Status:
Completed
Trial end date:
2010-12-01
Target enrollment:
Participant gender:
Summary
Introduction: Oxaliplatin (Ox) is a frequently used platinum-based medication that is a part
of many chemotherapy regimens for the treatment of several gastrointestinal malignancies. One
of the most important limitations to its use is the induction of both acute and chronic
peripheral neuropathy (PN). Previous studies have shown that vitamin E can reduce the
incidence of cisplatin-induced PN by 50%. In this study, the investigators aimed to determine
if vitamin E could also prevent Ox-induced acute PN