Vitamin k1 and Its Relation to Vascular Calcification in Hemodialysis Patients
Status:
Completed
Trial end date:
2020-01-01
Target enrollment:
Participant gender:
Summary
Vascular calcification (VC) represents one of the major complications associated with
progressive renal impairment. Matrix Gla-protein (MGP) is a vitamin K-dependent protein that
acts as a powerful inhibitor of vascular calcification. Despite this fact, it remains unknown
whether supplementation with vitamin K can lead to reduction or reversal of vascular and
heart valve calcification. Our study aims primarily to investigate the effect of intravenous
vitamin K1 three times weekly for a total duration of 6 months on the serum levels of
dephosphorylated-uncarboxylated MGP (dp-ucMGP) as well as aortic calcification score and
severity of aortic and mitral valve lesions.