Volatile Anaesthesia and Perioperative Outcomes Related to Cancer Feasibility Study

• Status: Unknown status
• Trial end date: 2020-06-30
• Target enrollment: 0
• Participant gender: All

Summary

A multicentre, prospective randomized, active-controlled feasibility trial of volatile-based anaesthesia vs. propofol-based total intravenous anaesthesia to investigate the impact of anaesthesia on long-term (i.e. 5-years) patient cancer outcomes in patients undergoing elective major cancer surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Peter MacCallum Cancer Centre, Australia
• Collaborators: M.D. Anderson Cancer Center; Melbourne Health; The Alfred
• Treatments: Anesthetics; Desflurane; Isoflurane; Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• Male or female

• Age 18-80 years

• Elective surgery

• Major cancer surgery expecting to last two or more hours, for:

• Breast (mastectomy or segmentectomy plus sentinel node dissection)

• Colorectal

• Lung

• Prostate

• Melanoma (excision of melanoma plus lymph node dissection AND/OR skin flap construction

• Other major cancer surgeries (e.g. oesophagectomy, head and neck cancer, etc.)

Exclusion Criteria

• Palliative surgery for end-stage disease with no curative intent

• Emergency surgery

• Extensive comorbid disease, i.e. American Society of Anesthesiologists (ASA) Score > 4

• Age <18 or >80 years old

• Refusal or inability to provide valid informed consent

• Risk of severe postoperative nausea and vomiting (PONV risk score >3)

• Previous allergy or contraindication to either anaesthetic medication

• Indication for gas induction of anaesthesia

• Currently enrolled in another clinical trial unless agreed by the coordinating principal investigator and site principal investigator that co-enrolment can occur.