Overview
Volume Kinetics for 20% Albumin in Different Clinical Situations
Status:
Unknown status
Unknown status
Trial end date:
2019-04-01
2019-04-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
The study aims to determine the degree of plasma volume expansion and the half-life of the plasma volume expansion when 3 mL/kg of hyperoncotic (20%) albumin if infused over 30 minutes in conscious healthy volunteers, in patients undergoing surgery under general anesthesia, and on the day after major surgery when the patient is in a post surgical inflammatory state. The study also examines the increase in the plasma colloid osmotic pressure as a result of this infusion and its possible influence on markers of kidney damage.Phase:
Phase 4Accepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
Sodertalje HospitalCollaborators:
Karolinska University Hospital
University Hospital, Linkoeping
Criteria
Inclusion Criteria:- Healthy volunteers.
- Patients in ASA classes I-II scheduled for surgery.
Exclusion Criteria:
- Expected major hemorrhage during surgery.
- Blood hemoglobin concentration of < 10 g/dL.