Volume Kinetics for Hyperoncotic Albumin in Burn Patients as Well as for Healthy Subjects
Status:
Completed
Trial end date:
2019-01-31
Target enrollment:
Participant gender:
Summary
Treatment with colloidal solutions has during long time been a cornerstone within intensive
care. Lately, doubts have been raised about synthetic colloids, and the natural albumin has
been used more and more.
One of these solutions is the hyperoncotic "Albumin 20%". However there are still many
aspects of the physiological effects of hyperoncotic albumin, that are not known. In this
study physiological effects will be studied in burn patients and healthy subjects. The
colloid osmotic pressure and the increase of the plasma volume will be measured in 15 healthy
subjects and in 15 burn patients. The effect on the plasma volume will be studied using
hemoglobin as a marker of dilution. Colloids osmotic pressure and albumin concentration will
be measured directly and urin production will also be measured. Blood samples will be
collected during 4 to 5 hours to achieve a profile over the changes.