Volumes of Administration for Intranasal Midazolam
Status:
Completed
Trial end date:
2015-09-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine exactly how much drug volume should be administered
into each nare, so that the drug absorption can be maximized and the amount that runs out of
the nose, or is swallowed, is minimized, thereby optimizing the effectiveness of any drug
given intranasally. The investigators will determine this ideal "volume of administration" by
studying intranasal midazolam in children who require sedation to facilitate laceration
repairs. The investigators will evaluate both clinical outcomes as well as pharmacokinetic
outcomes associated with each volume of administration. We will block randomize children to
receive intranasal midazolam in maximum aliquots of one of the three following VOA: 200
microliters (mcL), 500 mcL, or 1000 mcL.