Vorinostat, Irinotecan, Fluorouracil, and Leucovorin in Treating Patients With Advanced Upper Gastrointestinal Cancer
Status:
Completed
Trial end date:
2013-06-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Vorinostat may stop the growth of tumor cells by blocking some of the enzymes
needed for cell growth. Drugs used in chemotherapy, such as irinotecan, fluorouracil, and
leucovorin, work in different ways to stop the growth of tumor cells, either by killing the
cells or by stopping them from dividing. Giving vorinostat together with combination
chemotherapy may kill more tumor cells.
PURPOSE: This phase I trial is studying the side effects and best dose of vorinostat when
given together with irinotecan, fluorouracil, and leucovorin in treating patients with
advanced upper gastrointestinal cancer.