Overview

Vorinostat and Pegylated Liposomal Doxorubicin in Relapsed or Refractory Lymphomas

Status:
Terminated
Trial end date:
2011-09-01
Target enrollment:
Participant gender:
Summary
The study will be a dose-finding, phase I study of the combination of vorinostat and PLD in patients with advanced lymphoma refractory to at least one prior systemic therapy. The study will also be a dose-escalating study of vorinostat 200mg to 400 mg twice daily for 7 days with PLD 30mg/m2 on day 3 every 21 days, with intrapatient dose escalation.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
Yale University
Collaborator:
Merck Sharp & Dohme Corp.
Treatments:
Doxorubicin
Liposomal doxorubicin
Vorinostat