Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

This phase I trial is studying the side effects and best dose of vorinostat when given together with temozolomide in treating young patients with relapsed or refractory primary brain tumors or spinal cord tumors. Vorinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Vorinostat may help temozolomide work better by making tumor cells more sensitive to the drug.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Cancer Institute (NCI)
• Treatments: Dacarbazine; Temozolomide; Vorinostat

Criteria

Inclusion Criteria:

• Histologically confirmed CNS malignancy at original diagnosis or relapse

• Histologic confirmation not required for patients with intrinsic brain stem tumors, optic pathway gliomas, or pineal tumors provided CSF or serum tumor markers, including alpha-fetoprotein orbeta-HCG, are elevated

• Recurrent or refractory spinal cord tumors allowed

• Measurable or evaluable disease

• No known curative therapy or therapy proven to prolong survival with an acceptable quality of life

• Karnofsky performance status (PS) 50-100% (for patients > 16 years of age) OR Lansky PS 50-100% (for patients ≤ 16 years of age)

• Neurological deficits must have been relatively stable for ≥ 1 week before study entry

• Patients unable to walk due to paralysis, but who are up in a wheelchair, are considered ambulatory for the purpose of assessing performance status

• ANC ≥ 1,000/μL

• Platelet count ≥ 100,000/μL (transfusion independent, defined as no platelet transfusion within the past 7 days)

• Hemoglobin ≥ 8.0 g/dL (RBC transfusions allowed)

• Creatinine clearance or radioisotope GFR ≥ 70mL/min OR maximum serum creatinine based on age and/or gender as follows:

• 0.6 mg/dL (1 year of age)

• 0.8 mg/dL (2 to 5 years of age)

• 1.0 mg/dL (6 to 9 years of age)

• 1.2 mg/dL (10 to 12 years of age)

• 1.5 mg/dL (males) or 1.4 mg/dL (females) (13 to 15 years of age)

• 1.7 mg/dL (males) or 1.4 mg/dL (females) (≥ 16 years of age)

• Bilirubin ≤ 1.5 times upper limit of normal

• ALT ≤ 110 U/L

• Serum albumin ≥ 2 g/dL

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must use effective contraception

• Able to swallow capsules or liquid

• Seizure disorder allowed provided it is well controlled with nonenzyme-inducing anticonvulsants

• No pre-existing QTc ≥ 450 msec

• No uncontrolled infection

• No patients who, in the opinion of the investigator, may not be able to comply with the safety monitoring requirements of study

• Fully recovered from prior chemotherapy, immunotherapy, or radiotherapy

• More than 3 weeks since prior myelosuppressive chemotherapy (6 weeks for nitrosourea)

• At least 7 days since prior hematopoietic growth factors

• At least 7 days since prior biologic agent (antineoplastic agent)

• At least 7 days or 3 half-lives, whichever is longer, since prior monoclonal antibodies

• More than 2 weeks since prior local palliative radiotherapy (small port)

• At least 6 months since prior total-body radiotherapy (TBI), craniospinal radiotherapy, or radiotherapy to ≥ 50% of the pelvis

• At least 6 weeks since other prior substantial bone marrow radiotherapy

• At least 3 months since prior stem cell transplantation or rescue (without TBI)

• No evidence of active graft-vs-host disease

• At least 2 weeks since prior valproic acid

• No prior vorinostat

• Prior temozolomide allowed provided there was no progressive disease during or within 1 month after completion of treatment

• Concurrent corticosteroids allowed provided patient has been on a stable or decreasing dose for ≥ 7 days before study entry

• No other concurrent investigational drugs

• No other concurrent anticancer agents, including chemotherapy, radiotherapy, immunotherapy, or biologic therapy

• No concurrent enzyme-inducing anticonvulsants