Overview

Vorolanib (X-82) Combined With Checkpoint Inhibitors in Patients With Solid Tumors

Status:
Terminated
Trial end date:
2020-05-28
Target enrollment:
Participant gender:
Summary
The investigators hypothesize that vorolanib in combination with checkpoint inhibitors (pembrolizumab for gastric/gastroesophageal (GE) junction cancers and nivolumab for hepatocellular carcinoma (HCC)) may improve immunotherapy efficacy by overcoming treatment resistance of checkpoint inhibitors in gastrointestinal (GI) cancers.
Phase:
Phase 1
Details
Lead Sponsor:
Washington University School of Medicine
Collaborator:
Xcovery Holding Company, LLC
Treatments:
Antibodies, Monoclonal
Nivolumab
Pembrolizumab
Vorolanib