Depression in patients with type 2 diabetes is often undiagnosed and remains untreated,
leading to poor therapy adherence and ill health-related outcomes. The aim of study was
evaluated the effect of vortioxetine versus sertraline in the treatment of depression,
diabetes-related distress and control metabolic in subjects with type 2 diabetes and
depression. was included patients who were glycosylated hemoglobin ≥ 7.5%, 18 to 60 years of
age and written consent . Pharmacological treatment for depression was assigned randomly:
vortioxetine (10 mg/day) or sertraline (75 mg/day) for 8 weeks. Biochemical parameters,
anthropometric measures and depression symptoms were evaluated before and at the and at the 8
weeks after antidepressant treatment.