Walking the Isobole of Drug Interaction

• Status: Completed
• Trial end date: 2015-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators study whether four equipotent combinations of propofol and remifentanil (as predicted by interaction models for "tolerance of laryngoscopy") result in identical haemodynamic conditions, independent of their relative different balance between the concentration of propofol and remifentanil.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Medical Center Groningen
• Treatments: Propofol; Remifentanil

Criteria

Inclusion Criteria:

• Written informed consent

• General anesthesia required for the procedure

• Age: 18 years and older

• American Society of Anesthesiologists (ASA) physical status I to III

Exclusion Criteria:

• Refusal to participate in this study

• Contra-indications for the use of propofol or remifentanil

• BMI > 35 kg/m2

• Central nervous system disorders (i.e. cerebrovascular accident, dementia, seizures, psychiatric disorders)

• Relevant hepatic disease (Child B or higher)

• Regular use of medication that affects the central nervous system (i.e. benzodiazepines, antidepressants, antipsychotics, antiepileptic drugs)

• Use of alpha-agonists or beta-blockers

• Overt signs of alcohol abuse

• Use of preoperative benzodiazepines (on the day of the study)

• Beta blockers eye drips

• Overt signs of Drugs abuse