Overview

Weekly Paclitaxel and Cisplatin to Treat Hormone Receptor Positive and Triple Negative Breast Cancer Patients

Status:
Active, not recruiting

Trial end date:
2022-10-01

Target enrollment:
0

Participant gender:
Female

Summary

The investigators hypothesize that paclitaxel combined with cisplatin in a weekly-based regimen as neoadjuvant chemotherapy is effective and tolerable for locally advanced breast cancer. In patients with some sub-type advanced breast cancer, neo-adjuvant chemotherapy combined with endocrine therapy may improve the pathological remission rate. Premenopausal patients with triple negative breast caner and hormonal receptor positve breast cancer patients will be randominzed to have neoadjuvant chemotherapy combined with endocrine therapy or not.

Phase:

Phase 2/Phase 3

Accepts Healthy Volunteers?

Details

Lead Sponsor:

RenJi Hospital

Treatments:

Albumin-Bound Paclitaxel
Cisplatin
Hormones
Letrozole
Paclitaxel

Criteria

Inclusion Criteria:

1. Women aged ≥18years and ≤70 years;

2. At least on measurable disease according to the Response Evaluation Criteria in Solid
Tumors (RECIST). Histologically confirmed invasive breast cancer, tumor size ≥2 cm,
T2-4 N0-3M0;

3. ER/PR/HER-2 and Ki-67 status detected on core biopsy. ER and/or PR positive was
defined as >1% stained cells.HER2-positive is defined as immuno-histochemistry (IHC)
3+ or the ratio of HER2 gene signals to chromosome 17 signals >2.0 or HER2 gene copy
>6.0.

4. No prior systemic or loco-regional treatment of breast cancer;

5. Adequate bone marrow function:WBC≥4.0×109/L, Absolute neutrophil count（ANC）≥1.5×109/L,
Platelets（PLT）≥100×109/L, Hemoglobin（Hb）≥90g/L;aspartate aminotransferase(AST),Alanine
aminotransferase (ALT)≤1.5 upper normal limit (UNL), creatinine≤1.5 UNL,
bilirubin≤1.5UNL;

6. No obvious main organs dysfunction.

Exclusion Criteria:

1. Unwilling or unable to use an acceptable method of contraception in 8 weeks (including
8 weeks) after final dose of test drug;

2. Patient is pregnant or breast feeding;

3. Inflammatory breast cancer and metastatic breast cancer;

4. Any evidence of sense or motor nerve disorders;

5. Patients with medical conditions taht indicate intolerant to neoadjuvant therapy,
including uncontrolled cardiovascular disease, severe infection;

6. Any concurrent malignancy other than breast cancer;

7. Know severe hypersensitivity to any drugs in this study.