The investigators are conducting a study that will investigate the possible mechanisms of
weight loss associated with exenatide treatment and the metabolic characteristics of high
responders (i.e. subjects who achieve greater than 5% weight loss) to exenatide treatment.
The investigators will also examine the magnitude and duration of weight loss among a cohort
of high responders over 52 weeks of treatment, and at 3 and 6 months following treatment.
Hypothesis:
The mechanisms of weight loss with exenatide are not fully understood, and weight loss
responses to exenatide are highly variable, possibly reflecting distinct metabolic
parameters. By identifying and following a group of obese women who lose greater than 5% body
weight after short-term exenatide treatment, the investigators can gain insights into the
possible mechanisms of weight loss and assess long-term weight loss with this
pharmacotherapeutic intervention.