Whether Dexmedetomidine Can Improve the Prognosis of Elderly Patients With Postoperative Cognitive Dysfunction

• Status: Unknown status
• Trial end date: 2018-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether postoperative analgesia pump continuous infusion of dexmedetomidine are effective in the prevention of Postoperative delirium and Postoperative cognitive dysfunction.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Zhejiang Cancer Hospital
• Treatments: Dexmedetomidine; Dsuvia; Sufentanil

Criteria

Inclusion Criteria:

• Patients' age ≥65 years

• Underwent elective non-cardiac surgery under general anesthesia

Exclusion Criteria:

• Patients with severe bradycardia (heart rate<55bpm)

• Severe arrhythmia or cardiac dysfunction (ejection fraction<35%)

• Mini-Mental Scale Test (MMSE) Exclusion criteria: illiteracy <18, primary school <21, junior school and above <25

• Preoperative clear systems and spiritual history of neurological disease or long-term use of sedatives or antidepressants

• History of alcohol abuse or a history of drug dependence

• Have brain surgery or trauma

• Severe vision or hearing impairment

• Cannot with the completion of tests of cognitive function

• Refused to participate in the study