Whether Proton Pump Inhibitors, Administered Prior to or After Surgery, Can Reduce the Incidence and/or Severity of Difficulty Swallowing Foods and/or Liquids,Following Anterior Cervical Surgery

• Status: Withdrawn
• Trial end date: 2020-07-02
• Target enrollment: 0
• Participant gender: All

Summary

The researchers wish to investigate whether proton pump inhibitors, administered prior to or after surgery, can reduce the incidence and/or severity of difficulty swallowing foods and/or liquids,following anterior cervical surgery.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Icahn School of Medicine at Mount Sinai
• Treatments: Esomeprazole; Proton Pump Inhibitors

Criteria

Inclusion Criteria:

• Must be at least 18 years of age.

• Scheduled to undergo anterior cervical surgery for degenerative joint disease.

Exclusion Criteria:

• Patients undergoing revision procedures, multi-level procedures, or procedures treating conditions other than degenerative joint disease.

• Patients with preoperative dysphagia.

• Patients currently taking any acid suppressing medications (proton pump inhibitors, H2 blockers, antacids, etc).

• Patients who are pregnant or nursing.

• Patients who, due to drug allergies, hypersensitivities/anaphylactic reactions to esomeprazole or contraindications (hypersensitivity to benzimidazoles, osteoporosis), are unable to take esomeprazole.

• Patients unable to attend follow-up visits or answer the dysphagia questionnaires.

Eligibility Criteria:

• Scheduled to undergo anterior cervical surgery for degenerative joint disease.