Overview

WilL LOWer Dose Aspirin be More Effective Following ACS? (WILLOW-ACS)

Status:
Completed

Trial end date:
2017-04-07

Target enrollment:
0

Participant gender:
All

Summary

The study is going to compare two different doses of aspirin for the treatment of heart disease in combination with the anticlotting medication ticagrelor. One of these doses of aspirin, 75 milligrams (mg) once a day, is the current standard treatment dose of aspirin used to treat heart attacks and angina. The other, 20 mg twice a day, is lower than the standard but there is growing scientific evidence that, when given with ticagrelor, this might offer advantages over the usual dose.

Phase:

Phase 4

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Sheffield Teaching Hospitals NHS Foundation Trust

Treatments:

Aspirin

Criteria

Inclusion Criteria:

For inclusion in the study, subjects should fulfill the following criteria:

1. Provision of informed consent prior to any study specific procedures

2. Male or female aged greater than 18 years

3. Previous diagnosis of acute coronary syndrome greater than 30 days and less than 10
months before enrollment

4. Receiving dual antiplatelet therapy with aspirin 75 mg once daily and ticagrelor 90 mg
twice daily

Exclusion Criteria:

Subjects should not enter the study if any of the following exclusion criteria are
fulfilled:

1. Presence of an indication for dual antiplatelet therapy other than ischaemic heart
disease

2. PCI with drug eluting or bare metal stent(s) within 30 days of randomization

3. Any history of stent implantation to the left main coronary artery

4. Any history of stent thrombosis during dual antiplatelet therapy

5. Planned procedure for coronary revascularization

6. Any planned surgery or other procedure that may require suspension or discontinuation
of dual antiplatelet therapy expected to occur within 3 months of randomisation

7. Prior intention by patient or physician to discontinue aspirin and/or ticagrelor
within the study period

8. Receiving doses of aspirin and ticagrelor other than 75 mg once daily and 90mg twice
daily respectively