Women With Chest Pain and Normal Coronary Arteries Study
Status:
Terminated
Trial end date:
2010-05-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to compare the effectiveness of standard medical therapy versus
usual care in women with chest pain, coronary endothelial dysfunction and unblocked coronary
arteries.
Coronary endothelial dysfunction (CED) is a condition in which the layers of cells around the
heart do not function properly and is believed to be key factor in the development of
atherosclerosis (fat deposits in arteries). In addition, CED is associated with an increased
risk for future cardiovascular events, such as heart attack and stroke.
A coronary angiogram allows physicians to see if any of the arteries in the heart are
blocked, usually by fatty plaque. In many instances, angiograms in women experiencing chest
pain do not show evidence of coronary disease (free of significant plaque build-up).
Currently, there is no standard of care treatment plan for patients with normal coronary
arteries, despite symptoms of chest pain, and as a result these patients may not receive
medical treatment. However, these women often return to their physicians more than once with
chest pain and go through a similar battery of tests.