Women With Chest Pain and no Significant Coronary Artery Stenosis; A Study on Microvascular Resistance
Status:
Completed
Trial end date:
2016-06-01
Target enrollment:
Participant gender:
Summary
Female patients presenting with persistent chest pain despite no obstructive coronary artery
disease have impaired prognosis. Stress tests are often positive or inconclusive. As much as
20% of women with chest pain and minimal angiographic CAD have evidence of myocardial
ischemia, suggesting impaired coronary microcirculation. The index of microvascular
resistance (IMR) is a method for indirectly investigating microvascular function in the
cardiac catheterization laboratory.
66 female patients, age 30-70 years, with chest pain and "normal" or near normal coronary
angiograms will be included. After coronary physiologic evaluation, patients will be
randomized in a double blind study to rosuvastatin 20 mg/day or matching placebo tablets for
altogether 6 months.
The investigators hypothesize that:
1. A substantial number of women with chest pain and normal or minimal pathology on
angiograms have microvascular dysfunction defined by a raised IMR.
2. Statins, based on its pleiotropic action will improve endothelial function and thereby
IMR.