XELOX and XELIRI Alternative Regimen as First-line Treatment for Advanced Colorectal Cancer

• Status: Unknown status
• Trial end date: 2020-06-01

Summary

Colorectal cancer will be resistant to Chemotherapy drugs after treated for a period of time .In the past, the classical treatment regiment was to change other drug after tumor progressed. In theory, the continuous use of such a drug could shortening the patient's drug resistance time. It has been shown that the alternate use of the two drug combinations is reasonable in clinical. This application can not only further improve the curative effect but also significantly reduce the side effects. So the investigators are going to carry out a prospective phase II clinical study. The control group change to second-line treatment after progression of first-line drugs. The experimental group use the first line and the second line,alternately, for every two cycles. The combination of bevacizumab is a first line development, and the second line can still be used .Objective to compare the clinical value of XELOX and XELIRI alternation regimen in the first-line treatment of advanced colorectal cancer.

• Phase: Phase 2

Details

• Lead Sponsor: Harbin Medical University
• Collaborators: Cancer Institute and Hospital, Chinese Academy of Medical Sciences; First Affiliated Hospital of Harbin Medical University; First Hospital of Jilin University; Fudan University; Jilin Provincial Tumor Hospital; Liaoning Tumor Hospital & Institute; Shengjing Hospital; Sun Yat-sen University; The First Affiliated Hospital of Dalian Medical University; The First Hospital of Jilin University; The First People's Hospital of Jingzhou; The Second Affiliated Hospital of Harbin Medical University