Xenon Inhalation During Orthopaedic Surgery in Elderly Subjects.

• Status: Completed
• Trial end date: 2004-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The primary objective was to explore the feasibility of inhaled xenon for sedation in terms of its effect on postoperative cognitive function in elderly, in comparison with the postoperative cognitive function found after IV propofol sedation in the same population.The secondary objectives were designed to assess the feasibility of xenon sedation in terms of its effects on different neuropsycho-logical test variables, vital signs, sedation levels and safety in elderly orthopaedic subjects.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rigshospitalet, Denmark
• Collaborator: Linde AG
• Treatments: Propofol; Xenon

Criteria

Inclusion Criteria:

• Male or female subjects ≥ 60 years of age.

• American Soc. of Anaesthesiologists Physical Status Classification (ASA) I-III status [27]

• Referred for elective orthopaedic knee surgery with an anticipated duration of > 45 min

• Expected to remain in hospital for at least 3 days

• Expected to be able to comply with the study protocol throughout the study period

• Mini Mental State Examination (MMSE) score > 23

• Informed consent given

Exclusion Criteria:

• Disease of the CNS (infectious, metabolic, tumours, dementia, epilepsy, major psychiatric disease, confusion/ delirium according to Diagnostic & Statistical Manual of Mental Disorders (DSM) IV criteria)

• Contradiction for spinal anaesthesia

• Contradiction for laryngeal mask

• Regular use of tranquillisers, or antidepressants, if prescribed by psychiatrist for psychosis or depression

• Undergone neuropsychological testing within the last year

• Unable to follow study procedures, illiteracy, or poor comprehension of the language used in the psychometric tests

• Severe visual or auditory disorder

• Alcoholism or drug abuse

CNS disease BMI > 35 Inab