Xylitol for Chronic Sinusitis

• Status: Unknown status
• Trial end date: 2020-04-30
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this investigation is to conduct a randomized controlled trial within a subgroup of difficult-to-treat patients with CRS, evaluating the use of topical xylitol treatment concurrently with topical steroid/antibiotics combination in the effort to disrupt biofilms and improve disease control. The effectiveness of topical surfactants is a research gap in treating CRS but has promising correlates in other medical fields. Specifically, the investigators will be studying the effect of topical xylitol therapy on biofilm production with the use of PCR bacterial sequencing before and after medical intervention.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ochsner Health System
• Collaborator: Tulane University School of Medicine

Criteria

Inclusion Criteria:

• Adult patients above the age of 18

• History of chronic rhinosinusitis history who had undergone bilateral endoscopic sinus surgery to include at a minimum maxillary antrostomy and anterior ethmoidectomy.

• Continued chronic sinusitis that is refractory to medical therapy after surgical intervention

Exclusion Criteria:

• Patients under age of 18

• Non-English speaking

• History of immunodeficiency disease

• Cystic fibrosis

• Primary ciliary dyskinesia

• History of granulomatous disease

• Active smoker

• Treatment with antifungal medications

• Use of antifungal medications

• Acute bacterial infection requiring antibiotics

• Active pregnancy