Zinc Homeostasis and Kinetics in Children With Cystic Fibrosis (CF)

• Status: Completed
• Trial end date: 2007-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Zinc deficiency has occasionally been reported in CF, but the need for additional zinc is unclear. We will examine the effect of additional zinc supplements on zinc absorption, zinc excretion, zinc balance and zinc kinetics in children with CF. Twelve children with CF will receive additional zinc, and twelve will not. We will also compare the children with CF to 12 healthy children without CF. We hypothesize that children with CF will have poor zinc absorption and high zinc excretion, leading to poor zinc balance and abnormal zinc kinetics. We hypothesize that those children with CF who are given zinc supplements will have higher zinc balance and more normal zinc kinetics than those without supplementation, and that zinc balance and zinc kinetics will be similar to healthy children.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Cystic Fibrosis Foundation; Cystic Fibrosis Foundation Therapeutics
• Treatments: Zinc

Criteria

Inclusion Criteria:

• Aged 8-14 years old

• Have clinical pancreatic insufficiency (defined as the need for pancreatic enzyme replacement)

• Have no other medical problems except CF (and its complications)

• Weigh > 25kg

Exclusion Criteria:

• Are taking any medicines (other than for CF and its complications)

• Have known pancreatic endocrine dysfunction

• Are taking more than 10 mg/d elemental zinc supplements

• Have had major GI surgery, including gut resection, but not including surgery for decompression of meconium ileus (if this was the presenting feature of CF)