Zinc Supplementation on Very Low Birth Weight Infant

• Status: Unknown status
• Trial end date: 2020-07-31
• Target enrollment: 0
• Participant gender: All

Summary

Premature birth is a major cause of neonatal death in addition to neonatal asphyxia and infections.

Early in life, premature babies must get aggressive nutrition so that there is no extrauterine growth restriction (EUGR) in the Intrauterine Growth Restriction (IUGR) group compared to the non-IUGR group.

Other factors that also play a role are long episodes of fasting, the fulfillment of nutrition (macro and micronutrients) from the start, time to start breastfeeding (ASI), duration of parenteral total administration, the incidence of respiratory distress syndrome and incidence of necrotizing enterocolitis.

Zinc is one of the micronutrients which is very risky for deficiency in premature babies.

Babies with zinc deficiency experience growth disorders as much as 67%. In India, infants who received zinc supplementation increased after being given 10 days of zinc supplementation and lower mortality rates in the group with supplementation. Very low birth weight babies and bronchopulmonary dysplasia who received zinc supplementation during the week showed good clinical progress and the growth rate also increased.

The investigators believe this study has the potential for decreasing infant mortality from its current level and can be a growth indicator for preterm babies.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Fakultas Kedokteran Universitas Indonesia
• Treatments: Zinc; Zinc Sulfate

Criteria

Inclusion Criteria:

• Preterm (gestational age of 28 - 32 weeks)

• Newborns with a ratio of body weight and gestational age: Small for Gestational Age or Large for Gestational Age

• Get parental approval to be included in the study by signing an informed consent

Exclusion Criteria:

• Newborns with severe congenital abnormalities

• Newborns with digestive tract abnormalities: partial, total obstruction or gastrointestinal atresia

• Newborns with unstable hemodynamic conditions that will affect the survival rate

• Mothers who consume alcohol regularly (≧ 2x a month) during pregnancy

• Newborns with early-onset sepsis