α-Mangostin Hydrogel Film With Chitosan Alginate Base for Recurrent Aphthous Stomatitis (RAS)
Status:
Recruiting
Trial end date:
2024-12-20
Target enrollment:
Participant gender:
Summary
Recurrent Aphthous Stomatitis (RAS) is experienced by almost everyone and appears suddenly.
Even though the risk of death due to the condition is small, its presence can make a person
feel uncomfortable eating, drinking, and talking so there will be a decrease in the quality
of a person's life in their daily lives. Recently, α-Mangostin (α-M) from mangosteen rind
(Garcinia mangostana L) has been shown its effect to reduce oral mucosal sores on RAS in
preclinical studies in rats. Therefore, research is needed to prove the benefits (efficacy)
and safety of therapy in the form of a hydrogel film patch/plaster film with a chitosan
alginate base as a carrier for α-Mangostin for the treatment of RAS patients.