eIMPACT Trial: Modernized Collaborative Care to Reduce the Excess CVD Risk of Older Depressed Patients
Status:
Completed
Trial end date:
2021-03-01
Target enrollment:
Participant gender:
Summary
The objective of this randomized controlled trial is to evaluate whether the investigators
modernized IMPACT intervention for depression (eIMPACT), delivered before the onset of
cardiovascular disease (CVD), reduces the risk of future CVD. Participants will be primary
care patients who are depressed but do not have a history of CVD. Half of the participants
will receive standard depression treatment in primary care (usual care), and the other half
will receive one year of eIMPACT, a collaborative stepped care program including
antidepressants and computerized and telephonic cognitive-behavioral therapy. To evaluate
change in CVD risk, the investigators will measure artery function using ultrasound before
and after the 1-year treatment period. It is hypothesized that patients who receive the
eIMPACT intervention will have greater improvements in artery function than patients who
receive usual care.