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Clinical Trials for MELAS Syndrome

  • An Open-label Extension Safety Study of MELAS Patients Who Completed TIS6463-203 (PRIZM)
  • A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)
  • A Study to Assess TTI-0102 vs Placebo in MELAS Patients
  • KHENERFIN Study: A Trial to Evaluate the Efficacy and Safety of Sonlicromanol in Primary Mitochondrial Diseases
  • A Phase 2b Study of Zagociguat in Patients With MELAS
  • The KHENEREXT Study
  • Phase 2a Study of IW-6463 in Adults Diagnosed With MELAS
  • The KHENERGYZE Study
  • L-Citrulline Dose Finding Safety Study in MELAS
  • A Phase Ia/Ib, SAD and MAD Study of of KL1333 in Healthy Subjects and Patients With Primary Mitochondrial Disease
  • Safety, Tolerability and Pharmacokinetic Study of KL1333 in Healthy Male Volunteers
  • L-arginine Therapy on Endothelium-dependent Vasodilation & Mitochondrial Metabolism in MELAS Syndrome
  • Study of Idebenone in the Treatment of Mitochondrial Encephalopathy Lactic Acidosis & Stroke-like Episodes
  • Evaluating the Effectiveness of a Dichloroacetate in MELAS Syndrome
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