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Clinical Trials for MELAS Syndrome

• The KHENEREXT Study
• Phase 2a Study of IW-6463 in Adults Diagnosed With MELAS
• The KHENERGYZE Study
• L-Citrulline Dose Finding Safety Study in MELAS
• A Phase Ia/Ib, SAD and MAD Study of of KL1333 in Healthy Subjects and Patients With Primary Mitochondrial Disease
• Safety, Tolerability and Pharmacokinetic Study of KL1333 in Healthy Male Volunteers
• L-arginine Therapy on Endothelium-dependent Vasodilation & Mitochondrial Metabolism in MELAS Syndrome
• Study of Idebenone in the Treatment of Mitochondrial Encephalopathy Lactic Acidosis & Stroke-like Episodes
• Evaluating the Effectiveness of a Dichloroacetate in MELAS Syndrome