"Follow the Sutures". A New Procedure for Injection of Botulinum Toxin for Chronic Migraine
Status:
Completed
Trial end date:
2021-01-01
Target enrollment:
Participant gender:
Summary
There is no doubt that chronic migraine is a large public health problem, which is both
disabling and costly. Many patients and headache doctors see Botulinum toxin (Botox)
treatment as a big stride forward, but it is a problem that the effect has been shown in only
one study, with a low therapeutic gain. For this reason, before this costly treatment is
expanded to potentially several thousand patients in Norway, it would be highly desirable
that 1) there is additional good scientific evidence for use of Botox , 2) a more effective
treatment procedure is developed, 3) the potential for unblinding is reduced, and 4) the
dose, number of injection sites and cost can be halved, and 5) the adverse effects are
minimized. These may be the results of this pilot project where injections are given along
the sutures, which can open up for a later randomized, blinded and controlled study.
Phase:
Phase 2
Details
Lead Sponsor:
Norwegian University of Science and Technology
Collaborators:
Mayo Clinic St. Olavs Hospital
Treatments:
abobotulinumtoxinA Botulinum Toxins Botulinum Toxins, Type A incobotulinumtoxinA onabotulinumtoxinA