"Overlap Syndrome and PSC: Evaluating Role of Gut Microflora and Its Identification With Antibiotics in Children"
Status:
Unknown status
Trial end date:
2020-12-01
Target enrollment:
Participant gender:
Summary
Based upon the possible implication of microbiota and abnormal microbial metabolites such as
altered bile acids, in the pathogenesis of PSC, emerging data suggests that oral antibiotics,
such as vancomycin and metronidazole, may have therapeutic effects in this overlap syndrome
or PSC.
The goal of our study is to evaluate role of antibiotics and microflora in children with
AIH/PSC overlap syndrome or with PSC alone. The investigators hope to learn what effects oral
antibiotics has on the bacteria present in stool, and hope to learn to characterize human
intestinal microbial communities, in children suffering from overlap syndrome or PSC.
The hypothesis of the investigators is that overlap syndrome and PSC develop due to altered
microflora and the resulting abnormal bile acids pool. The outcome of overlap syndrome or PSC
could be affected by presence or absence of RCUH. Antibiotics to correct the microflora may
result in disease/cholangiopathy remission.
Phase:
N/A
Details
Lead Sponsor:
Cliniques universitaires Saint-Luc- Université Catholique de Louvain