sTep dOWn Inhalers in the reAl woRlD

• Status: Unknown status
• Trial end date: 2019-08-31
• Target enrollment: 0
• Participant gender: All

Summary

To establish the feasibility of stopping inhaled steroids and switching or maintaining dual bronchodilation in one visit - in the real world, for people with COPD.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hywel Dda Health Board
• Collaborator: Swansea University
• Treatments: Muscarinic Antagonists

Criteria

Inclusion Criteria:

• GP diagnosis of COPD

• Post bronchodilator FEV1/FVC ratio <70% with FEV1<80% predicted

• Current or ex smoker equal or greater than 10 pack years

• Taking an ICS, LABA & LAMA

Exclusion Criteria:

• Unable or unwilling to sign informed consent

• Any previous or current diagnosis of asthma

• Any features of asthma or large variability in symptoms

• History of atopy

• Any previous blood eosinophil count >600mm3

• A moderate or severe exacerbation of COPD (needing systemic glucocorticosteroids or hospital admission for >24 hours) within the last 6 weeks

• Life expectancy < 1 year