the Effect of Dexmedetomidine and Magnesium Sulfate in Open Resection of Pheochromocytoma
Status:
Completed
Trial end date:
2021-08-30
Target enrollment:
Participant gender:
Summary
Pheochromocytoma (pheo) is a catecholamine secreting tumor arising from chromaffin cells of
the adrenal medulla in 90% of cases & in 10% is extra-adrenal arising from the sympathetic
chain. It is malignant in 10% of cases, bilateral in 10% of patients & 10% of all pheo are
inherited (Familial Pheo) as autosomal dominant either alone or as a part of multiple
endocrine neoplasia (MEN) syndrome.In this prospective work, the investigators will try to
compare the peri-operative hemodynamic course of Dexmedetomidine & magnesium sulphate (MgSo₄)
infused patients with the traditional anesthetic technique (α₁ & β-adrenergic blockers plus
vasodilators) during open surgical resection of Pheo. The investigators are aiming to check
the safety & efficacy of the recommended technique on the peri-operative hemodynamic
stability & controlling the hypertensive crisis during tumor manipulation.
Phase:
Phase 2
Details
Lead Sponsor:
National Cancer Institute, Egypt
Treatments:
Anesthetics Anesthetics, General Dexmedetomidine Magnesium Sulfate