the Effect of Tracleer on Tourniquet-associated Hypertension
Status:
Unknown status
Trial end date:
2018-05-01
Target enrollment:
Participant gender:
Summary
Tourniquet is widely used in orthopedic surgery. However, prolonged tourniquet inflation may
cause a gradual rise in blood pressure, which named as tourniquet-associated hypertension.
Thus, to effectively prevent the tourniquet related hemodynamic responses is important for
patients receiving limb surgery.
Tracleer is an endothelin receptor antagonist indicated for the treatment of pulmonary
arterial hypertension. Tracleer can also be used to treat retistant hypertension. At present
trial, the investigators are going to investigate the effect of Tracleer on
tourniquet-associated hypertension during total knee arthroplasty.