the Efficacy of 0.01% Atropine for Near Work-induced Transient Myopia and Myopic Progression
Status:
Recruiting
Trial end date:
2025-05-31
Target enrollment:
Participant gender:
Summary
Near work-induced transient myopia (NITM) is an important factor in permanent myopia (PM)
development and progression. Atropine eye drop is beneficial in reducing initial NITM and
slowing down myopic progression.Participants were randomly assigned in a 1:1 ratio to receive
0.01% atropine or placebo eye drop once nightly bilaterally for one year. Initial NITM,
cycloplegic refraction, axial length (AL), best-corrected visual acuity (BCVA), intraocular
pressure (IOP), and pupil diameter will be measured at baseline, 4-week, 12-week, 24-week,
36-week, and 48-week. Visual Function Questionnaire was administered at baseline and each
follow-up visit. Adverse events also will be monitored and documented at each subsequent
follow-up visit. This study investigates the efficacy of 0.01% atropine in the treatment of
NITM and its possible association with the progression of refractive change in Chinese myopic
children.