the Microbiota Are Associated With Iodine-131 Therapy and Hypothyroidism
Status:
Recruiting
Trial end date:
2022-05-01
Target enrollment:
Participant gender:
Summary
Thyroid cancer is a common neck malignancy. Currently, total thyroidectomy or subtotal
thyroidectomy is the main method for the treatment of thyroid cancer patients. However, some
thyroid cancer may still have residual thyroid tissue after operation. Therefore, in the
differentiated thyroid In the treatment of cancer, iodine 131 treatment is mainly used
because iodine 131 can emit high-energy beta rays, destroying the residual tissue of thyroid
cancer and achieving good therapeutic goals. However, in the treatment of iodine-131, certain
salivary glands are inevitably damaged, and the patient will have dry mouth symptoms. After
the same treatment with iodine-131, some patients will experience gastrointestinal reactions
such as nausea and vomiting. The therapeutic efficacy of iodine-131 depends on the lesion's
uptake of iodine-131, which requires an increase in serum TSH levels. All patients in this
study had stopped taking thyroid hormone for 3-4 weeks before iodine 131 treatment, making
serum The TSH level is greater than 30 mU/L. At this time, the patient is in hypothyroidism.
People with hypothyroidism experience dry mouth, dry skin, constipation, pain, cold, poor
memory, depression, and weight gain. Many studies have pointed out that some cancer
treatments, such as chemotherapy and radiotherapy, also have an impact on the microbial
flora. However, studies on the relationship between microecology, hypothyroidism and
iodine-131 treatment, probiotics in the prevention of hypothyroidism and iodine-131 treatment
The link between the effects of side effects remains unclear. Therefore, the team will
conduct a correlation study between microbes and hypothyroidism, iodine-131 treatment.
Phase:
Early Phase 1
Details
Lead Sponsor:
First Affiliated Hospital of Harbin Medical University