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Clinical Trials for Blindness

• A Safety and Efficacy Study of HG004 in Subjects With Leber Congenital Amaurosis
• An Open-label, Dose Escalation and Double-masked, Randomized, Controlled Trial Evaluating Safety and Tolerability of Sepofarsen in Children (<8 Years of Age) With LCA10 Caused by Mutations in the CEP290 Gene.
• RPE65 Gene Therapy （LX101）for Leber's Congenital Amaurosis
• Safety and Efficacy of CRISPR/Cas9 mRNA Instantaneous Gene Editing Therapy to Treat Refractory Viral Keratitis
• Study of Subretinally Injected SAR439483 Administered in Patients With Leber Congenital Amaurosis Caused by Biallelic Mutations in GUCY2D
• A Study to Evaluate Efficacy, Safety, Tolerability and Exposure After a Repeat-dose of Sepofarsen (QR-110) in LCA10 (ILLUMINATE)
• Extension Study to Study PQ-110-001 (NCT03140969)
• Single Ascending Dose Study in Participants With LCA10
• Study of the Benefit of Early Treatment With an Endothelin Inhibitor (Bosentan) in Patients With Sudden Blindness Due to Giant Cell Arteritis: CECIBO
• Study to Evaluate QR-110 in Leber's Congenital Amaurosis (LCA) Due to the c.2991+1655A>G Mutation (p.Cys998X) in the CEP290 Gene
• Revacept in Symptomatic Carotid Stenosis
• Repeated Treatments of QLT091001 in Subjects With Leber Congenital Amaurosis or Retinitis Pigmentosa (Extension of Study RET IRD 01)
• Clinical Gene Therapy Protocol for the Treatment of Retinal Dystrophy Caused by Defects in RPE65
• Infliximab to Improve Retention of the Boston Keratoprosthesis in Patients After Stevens Johnson Syndrome/ Toxic Epidermal Necrolysis (SJS/TENS)
• Effects of Sevoflurane and Propofol on Light Flashed Evoked Pupillometry
• Trial of Lithium Carbonate for Treatment of Osteoporosis-pseudoglioma Syndrome
• Safety/Proof of Concept Study of Oral QLT091001 in Subjects With Leber Congenital Amaurosis (LCA) or Retinitis Pigmentosa (RP) Due to Retinal Pigment Epithelial 65 Protein (RPE65) or Lecithin:Retinol Acyltransferase (LRAT) Mutations
• Efficacy and Safety of Circadin for Non-24 Hour Sleep-Wake Disorder in Totally Blind Subjects
• Melatonin for Circadian Sleep Disorders in the Blind
• Melatonin Studies of Totally Blind Children
• Melatonin for Circadian Sleep Disorders in the Blind
• Efficient Study of ACULAR in Inhibiting Proliferative Retinopathy in Prematurity
• A Clinical Trial of Povidone-Iodine for the Treatment of Bacterial Corneal Ulcers
• The Extract of Green Tea on Obese Women: a Randomized Double Blindness Clinical Trial
• Healthy Volunteer Study of Sildenafil Effects Upon Vision
• The Connection Between Areas in the Brain of Blind Patients
• Early Treatment Diabetic Retinopathy Study (ETDRS)