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Clinical Trials for Down Syndrome

• Oxygen Therapy in Children and Adolescents With Down Syndrome and Obstructive Sleep Apnea
• Guanfacine for Hyperactivity in Children With Down Syndrome (HYPEbeGONE_DS)
• Phase 1/2 Trial of AEF0217 in Participants With Down Syndrome
• Therapies for Down Syndrome Regression Disorder
• Phase II Trial to Evaluate Safety and Efficacy of GM-CSF /Sargramostim in Down Syndrome
• Fluoxetine Treatment of Depression in Down Syndrome
• Sensitivity of the NIH Toolbox to Stimulant Treatment in Intellectual Disabilities
• Cholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and Cognition
• the Effect of Cerebrolysin on Physical and Mental Functions of Down Syndrome
• Use of Liquid Stable Levothyroxine in Trisomy 21 Pediatric Patients
• A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)
• GnRH Therapy on Cognition in Down Syndrome
• Tofacitinib for Immune Skin Conditions in Down Syndrome
• Evaluating Treatment of ADHD in Children With Down Syndrome
• Medications for Obstructive Sleep Apnea In Children With Down Syndrome
• A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia
• ASIA Down Syndrome Acute Lymphoblastic Leukemia 2016
• The Effects of Inhalational Anaesthetics in Cognitive Functions in Down Syndrome Patients
• Antimicrobial Photodynamic Therapy as an Adjunct Treatment for Periodontal Disease in Down's Syndrome Patients
• Basmisanil Positron Emission Tomography Study in Japanese Volunteers
• Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome
• A Study of RO5186582 in Down Syndrome Among Children 6 to 11 Years of Age
• Investigation of the Safety of Intranasal Glulisine in Down Syndrome
• Down Syndrome Memantine Follow-up Study
• A Double-blind, Placebo-controlled Comparative Study and Open-label Extension Study to Confirm the Efficacy and Safety of E2020 in Subjects With Down Syndrome Having Regression Symptoms and Disabled Activities of Daily Living.
• A Study of RG1662 in Adults and Adolescents With Down Syndrome (CLEMATIS)
• Fluor Varnish With Silver Nanoparticles for Dental Remineralization in Patients With Trisomy 21
• Treatment Trial of Subclinical Hypothyroidism in Down Syndrome
• A 4-Week Safety Study of Oral ELND005 in Young Adults With Down Syndrome Without Dementia
• Nicotine Treatment of Cognitive Decline in Down Syndrome
• A Molecular and Functional Brain Imaging Study in Individuals With Down Syndrome and Healthy Controls Following Single Dose RG1662
• Multicenter Vitamin E Trial in Aging Persons With Down Syndrome
• Efficacy Assessment of Systematic Treatment With Folinic Acid and Thyroid Hormone on Psychomotor Development of Down Syndrome Young Children
• A Study of RG1662 in Individuals With Down Syndrome
• Egcg, a dyrk1a Inhibitor as Therapeutic Tool for Reversing Cognitive Deficits in Down Syndrome Individuals.
• MK2206 in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Leukemia
• Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma
• Efficacy and Safety of Memantine Hydrochloride in Enhancing the Cognitive Abilities of Young Adults With Down Syndrome
• Rivastigmine Study in Adolescents With Down Syndrome
• Phase II Study of Florbetaben (BAY94-9172) PET Imaging for Detection/Exclusion of Cerebral β-amyloid.
• Liq-NOL Efficacy in Pediatric Patients With Down Syndrome
• Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome, Aged 11 To 17
• Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome, Aged 6 To 10
• Efficacy of Rivastigmine in Patients With Down Syndrome
• Evaluating The Safety Of Donepezil Hydrochloride (Aricept) For Up To 1 Year In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome - Follow-Up To A 10-Week, Double-Blind, Placebo-Controlled Trial
• Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (HCl) (Aricept) In Treating Cognitive Dysfunction Exhibited By Children With Down Syndrome
• Low-Dose Cytarabine in Treating Infants With Down Syndrome and Transient Myeloproliferative Disorder
• Vitamins and Minerals for Children With Downs Syndrome
• Combination Chemotherapy in Treating Young Patients With Down Syndrome and Acute Myeloid Leukemia or Myelodysplastic Syndromes
• Low-Dose or High-Dose Conditioning Followed by Peripheral Blood Stem Cell Transplant in Treating Patients With Myelodysplastic Syndrome or Acute Myelogenous Leukemia
• Efficacy Study of Folinic Acid to Improve Mental Development of Children With Down Syndrome
• Memantine and Down's Syndrome
• Vitamin E in Aging Persons With Down Syndrome
• Fludarabine Phosphate and Total-Body Radiation Followed by Donor Peripheral Blood Stem Cell Transplant and Immunosuppression in Treating Patients With Hematologic Malignancies
• Chemotherapy in Treating Children With Down Syndrome and Myeloproliferative Disorder, Acute Myelogenous Leukemia, or Myelodysplastic Syndrome