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Clinical Trials for Huntington Disease

• A Safety and Pharmacokinetics Trial of VO659 in SCA1, SCA3 and HD
• A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared With Placebo in Participants With Prodromal and Early Manifest Huntington's Disease.
• A Study to Evaluate the Safety and Tolerability of SAGE-718 in Participants With Huntington's Disease
• A Randomised Controlled Trial, Of N-Acetyl Cysteine (NAC), for Premanifest Huntingtin Gene Expansion Carriers
• Efficacy and Safety on SOM3355 in Huntington's Disease Chorea
• A Study to Evaluate the Effect of SAGE-718 on Functioning Capacity in Participants With Huntington's Disease
• A Study to Evaluate the Safety and Efficacy of PTC518 in Participants With Huntington's Disease (HD)
• A Dose-escalation Study to Evaluate the Safety, Tolerability and Pharmacokinetic of LPM3770164 in Healthy Subjects
• A Dose Range Finding Study With Open-Label Extension to Evaluate the Safety of Oral LMI070/Branaplam in Early Manifest Huntington's Disease
• A Study to Evaluate the Effect of SAGE-718 on Cognitive Function in Participants With Huntington's Disease (HD)
• Study of WVE-003 in Patients With Huntington's Disease
• TEsting METformin Against Cognitive Decline in HD
• Impact of Deutetrabenazine on Functional Speech and Gait Dynamics in Huntington Disease
• Open-label Extension Study to Evaluate the Safety and Tolerability of WVE-120102 in Patients With Huntington's Disease
• Open-label Extension Study to Evaluate the Safety and Tolerability of WVE-120101 in Patients With Huntington's Disease
• PRidopidine's Outcome On Function in Huntington Disease, PROOF- HD
• An Open Label Study of ANX005 in Subjects With, or at Risk for, Manifest Huntington's Disease
• Trial of the Combined Use of Thiamine and Biotin in Patients With Huntington's Disease
• Open-Label Rollover Study for Continuing Valbenazine Administration for the Treatment of Chorea Associated With Huntington Disease
• Efficacy of Deutetrabenazine to Control Symptoms of Dysphagia Associated With HD
• Risperidone for the Treatment of Huntington's Disease Involuntary Movements
• Efficacy, Safety, and Tolerability of Valbenazine for the Treatment of Chorea Associated With Huntington Disease
• Symptomatic Therapy for Patients With Huntington's Disease
• A Study to Investigate the Pharmacokinetics and Pharmacodynamics of RO7234292 (RG6042) in CSF and Plasma, and Safety and Tolerability Following Intrathecal Administration in Patients With Huntington's Disease
• Within Subject Crossover Study of Cognitive Effects of Neflamapimod in Early-Stage Huntington Disease
• Evaluating the Efficacy of Dextromethorphan/Quinidine in Treating Irritability in Huntington's Disease
• An Open-Label Extension Study to Evaluate Long-Term Safety and Tolerability of RO7234292 (RG6042) in Huntington's Disease Patients Who Participated in Prior Roche and Genentech Sponsored Studies
• A Study to Evaluate Safety, Tolerability, and Pharmacokinetics of SAGE-718 Oral Solution in Patients With Huntington's Disease - Part B
• Nilotinib in Huntington's Disease
• A Study to Evaluate the Efficacy and Safety of Intrathecally Administered RO7234292 (RG6042) in Participants With Manifest Huntington's Disease
• CKD-504 in SAD and MAD in Healthy Korean and Caucasian Adult Male and Female Subjects
• Efficacy and Safety of SOM3355 in Huntington's Disease Chorea
• Safety and Efficacy of Fenofibrate as a Treatment for Huntington's Disease
• A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7234292 (ISIS 443139) in Huntington's Disease Patients Who Participated in Prior Investigational Studies of RO7234292 (ISIS 443139)
• Safety and Tolerability of WVE-120102 in Patients With Huntington's Disease
• Safety and Tolerability of WVE-120101 in Patients With Huntington's Disease
• A Study to Evaluate Sigma-1 and Dopamine-2 Receptor Occupancy by Pridopidine in the Human Brain of Healthy Volunteers and in Patients With Huntington's Disease
• Study to Assess the Safety, Tolerability and Pharmacokinetic Profile of PBF-999 "After Multiple Oral Doses" in Healthy Volunteers
• Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ISIS 443139 in Participants With Early Manifest Huntington's Disease
• A Pilot Study Assessing Impulsivity in Patients With Huntington's Disease on Xenazine (Tetrabenazine)
• Tolerability, Safety, and Activity of SRX246 in Irritable Subjects With Huntington's Disease
• A Study Evaluating if Pridopidine is Safe, Efficacious, and Tolerable in Patients With Huntington's Disease
• A Study in Subjects With Late Prodromal and Early Manifest Huntington's Disease (HD) to Assess the Safety, Tolerability, Pharmacokinetics, and Efficacy of Pepinemab (VX15/2503)
• A Comparative Phase 2 Study Assessing the Efficacy of Triheptanoin, an Anaplerotic Therapy in Huntington's Disease
• Open Label Extension Study To Investigate Long Term Safety, Tolerability And Efficacy Of Pf-02545920 In Subjects With Huntington's Disease Who Completed Study A8241021
• Study Exploring Safety, Pharmacokinetic and Pharmacodynamic of BN82451 in Male Huntington's Disease Patients
• A Clinical Study in Participants With Huntington's Disease (HD) to Assess Efficacy and Safety of Three Oral Doses of Laquinimod
• Study To Assess the Safety and Tolerability of Single Ascending Oral Doses of PBF-999 in Healthy Young Male Volunteers
• Randomized, Placebo Controlled Study Of The Efficacy And Safety Of PF-02545920 In Subjects With Huntington's Disease
• Multicentric Trial of the Treatment of Huntington's Disease by Cysteamine (RP103)
• Safety and Efficacy of OMS643762 in Subjects With Huntington's Disease
• A Phase 2, to Evaluating the Safety and Efficacy of Pridopidine Vs Placebo for Symptomatic Treatment in Patients With Huntington's Disease
• Apathy Cure Through Bupropion in Huntington's Disease
• Alternatives for Reducing Chorea in Huntington Disease
• Proof of Concept of an Anaplerotic Study Using Brain Phosphorus Magnetic Resonance Spectroscopy in Huntington Disease
• Effect of Tetrabenazine on Stroop Interference in HD
• Study Evaluating The Safety, Tolerability And Brain Function Of 2 Doses Of PF-0254920 In Subjects With Early Huntington's Disease
• First Time Use of SD-809 in Huntington Disease
• Healthy Volunteer Positron Emission Tomography (PET) Brain Occupancy Study of a Phosphodiesterase 4 (PDE4) Inhibitor in Huntington's Disease
• Effect of PBT2 in Patients With Early to Mid Stage Huntington Disease
• A Repeat Dose Study in Healthy Volunteers Investigating Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK356278
• Escalating Dose Study in Healthy Volunteers With SEN0014196
• A Phase II Safety and Tolerability Study With SEN0014196
• Neuroprotection by Cannabinoids in Huntington's Disease
• A Open-label Food Effect Study With SEN0014196 in Subjects With Huntington Disease
• An Exploratory Clinical Trial in Early Stage Huntington's Disease Patients With SEN0014196
• A Trial of Memantine as Symptomatic Treatment for Early Huntington Disease
• Creatine Safety & Tolerability in Huntington's Disease
• Premanifest Huntington's Disease Extension Study II: Creatine Safety & Tolerability
• Premanifest Huntington's Disease: Creatine Safety & Tolerability Extension Study
• Effects of EGCG (Epigallocatechin Gallate) in Huntington's Disease (ETON-Study)
• Open-label Extension Study of Pridopidine (ACR16) in the Symptomatic Treatment of Huntington Disease
• An Extension of the HORIZON Protocol Evaluating the Safety of Dimebon (Latrepirdine) in Subjects With Huntington Disease
• Efficacy, Safety and Tolerability of AFQ056 in Patients With Huntington's Disease in Reducing Chorea
• A Study Evaluating The Absorption Of Dimebon Into The Body From A Dimebon Solution Applied To The Skin
• A Study In Healthy Volunteers To Estimate The Pharmacokinetics Of Four Modified-Release Formulations Of Dimebon (Latrepirdine)
• A Study To Evaluate The Abuse Potential Of Single Oral Doses Of Dimebon (Latrepirdine) In Healthy Recreational Polydrug Users
• Evaluation of [123I]MNI-420 and SPECT as a Marker of the Adenosine A2a Receptor in PD, HD and Healthy Subjects.
• A Phase I Study To Estimate The Effect Of Ketoconazole And Omeprazole On The Pharmacokinetics Of Dimebon In Healthy Subjects Who Are Normal Or Poor CYP2D6 Metabolizers
• A Safety and Efficacy Study of Dimebon in Patients With Huntington Disease
• Study in PRE-manifest Huntington's Disease of Coenzyme Q10 (UbiquinonE) Leading to Preventive Trials (PREQUEL)
• Treating Sleep/Wake Cycle Disturbances in Basal Ganglia Disorders With Ramelteon
• A PET Brain Imaging Study of mGluR5 in Subjects With Neuropsychiatric Conditions
• Dimebon (PF-01913539)-Digoxin Drug-Drug Interaction Study In Healthy Subjects
• A Phase 1, Randomized, Open-Label, Two-Way Crossover Study To Evaluate The Steady-State Effect Of Dimebon (PF 01913539) On The Single-Dose Pharmacokinetics And Pharmacodynamics Of Warfarin In Healthy Subjects
• A Phase 1 Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Dimebon [PF-01913539] In Japanese And Western Healthy Subjects
• A Phase 1, Non-Randomized, Open-Label, Single-Dose Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Dimebon [PF 01913539] In Subjects With Severely-Impaired And Normal Renal Function
• A Phase 1 Study To Evaluate The Effect Of Dimebon On The Pharmacokinetics Of Dextromethorphan
• A Study of Pridopidine (ACR16) for the Treatment of Patients With Huntington's Disease
• Creatine Safety, Tolerability, & Efficacy in Huntington's Disease (CREST-E)
• A Study of Treatment With Pridopidine (ACR16) in Patients With Huntington's Disease
• Study of Memantine to Treat Huntington's Disease
• Neuroleptic and Huntington Disease Comparison of : Olanzapine, la Tetrabenazine and Tiapride
• Coenzyme Q10 in Huntington's Disease (HD)
• Creatine Safety and Tolerability in Premanifest HD: PRECREST
• Ursodiol in Huntington's Disease
• A Study of the Novel Drug Dimebon in Patients With Huntington's Disease
• Safety Study of the Novel Drug Dimebon to Treat Patients With Huntington's Disease
• Atomoxetine and Huntington's Disease
• Riluzole in Huntington's Disease
• Pilot Study of Minocycline in Huntington's Disease
• Citalopram to Enhance Cognition in HD
• Efficacy and Safety of Tetrabenazine in Chorea
• Safety and Tolerability Study of Phenylbutyrate in Huntington's Disease (PHEND-HD)
• TREND-HD - A Trial of Ethyl-EPA (Miraxion™) in Treating Mild to Moderate Huntington's Disease
• Effects of Lithium and Divalproex'on Brain-Derived Neurotrophic Factor in Huntington's Disease
• Minocycline in Patients With Huntington's Disease
• Creatine Therapy for Huntington's Disease
• Treatment of Huntington's Chorea With Amantadine