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Clinical Trials for Hyperkalemia

• 5 Versus 10 Units of Insulin in Hyperkalemia Management
• Patiromer Trial in CKD Stage IIIB to V
• Patiromer for Treatment of Hyperkalaemia in Children From Birth to <6 Years of Age
• Nebulized Salbutamol Facilitate Management of Hyperkalemia Postreperfusion During Liver Transplantation
• A Prospective, Randomized, Open-Label, Cross-Over Study of Lokelma to Control Interdialytic Hyperkalemia
• Sodium Zirconium Cyclosilicate Lowers Hyperkalemia After Parathyroidectomy
• Continuing Sodium Zirconium Cyclosilicate (SZC) After Discharge Study
• Levalbuterol Compared to Albuterol Regarding Cardiac Side Effects and Potassium Lowering Effects.
• Trial Evaluating the Efficacy and Safety of Patiromer in Chinese Subjects
• A Study to Evaluate the Effect of Sodium Zirconium Cyclosilicate on Chronic Kidney Disease (CKD) Progression in Participants With CKD and Hyperkalaemia or at Risk of Hyperkalaemia
• Effects of Patiromer on Pharmacokinetics of Immunosuppresive Drugs in Renal Transplant Recipients
• Lokelma for RAAS Maximisation in CKD & Heart Failure.
• Study of SZC and Enhanced Nutrition Advice Compared to SoC in Dialysis Patients With Hyperkalaemia
• The ORTIZ Study: Optimising RASi Therapy With SZC
• A Comparative Study of ZG-801 and Placebo in Patients With Hyperkalemia
• Effect of Sodium Zirconium Cyclosilicate on Arrythmia-related Cardiovascular Outcomes in Participants on Chronic Hemodialysis With Recurrent Hyperkalemia (DIALIZE-Outcomes)
• OPtimizing Aldosterone Receptor Antagonist Therapy by Sodium Zirconium Cyclosilicate in Heart Failure
• Study to Assess the Effect of Sodium Zirconium Cyclosilicate on the Pharmacokinetics of Tacrolimus and Cyclosporin in Healthy Subjects
• A Study Evaluating the Safety and Efficacy of RDX013 for the Treatment of Hyperkalemia
• Potassium Binder in CKD Patients (With Hyperkalemia) (DiPo Trial)
• Study of the Effect of SZC on Serum Potassium and Serum Bicarbonate in Patients With Hyperkalemia and Metabolic Acidosis Associated With Chronic Kidney Disease
• Study to Assess Efficacy and Safety of SZC for the Management of High Potassium in Patients With Symptomatic HFrEF Receiving Spironolactone
• Comparison of Potassium Binders in the ER
• Patiromer Utility as an Adjunct Treatment in Patients Needing Urgent Hyperkalemia Management
• Reduce Incidence of Pre-Dialysis Hyperkalaemia With Sodium Zirconium Cyclosilicate in Chinese Subjects
• The Effect of Sodium Zirconium Cyclosilicate on Albuminuria in Patients With Type 2 Diabetes and Hyperkalemia
• Insulin Dextrose Infusion vs Nebulized Salbutamol vs Combination of Salbutamol and Insulin Dextrose in Acute Hyperkalemia
• Patiromer for the Management of Hyperkalemia in Subjects Receiving RAASi Medications for the Treatment of Heart Failure (DIAMOND)
• A Study in Children With Hyperkalaemia Between Birth and <18 Years of Age to Evaluate Doses of Sodium Zirconium Cyclosilicate (SZC) for Correction of Hyperkalaemia and Effectiveness of Same Dose to Maintain Normokalaemia.
• Exploratory Study of ZG-801 for the Treatment of Hyperkalemia
• Patiromer Efficacy to Reduce Episodic Hyperkalemia in End Stage Renal Disease Patients
• Mineralocorticoid Receptor Antagonism Clinical Evaluation in Atherosclerosis Add-On
• A Study to Investigate the Safety and Efficacy of ZS in Patients With Hyperkalemia.
• A Study to Evaluate a Potassium Normalization Treatment Regimen Including Sodium Zirconium Cyclosilicate (ZS) Among Patients With S-K ≥5.8
• The Effects of Patiromer on Serum Potassium Level and Gut Microbiome of ESRD Patients With Hyperkalemia
• A Study to Test Whether ZS (Sodium Zirconium Cyclosilicate) Can Reduce the Incidence of Increased Blood Potassium Levels Among Dialized Patients.
• A Safety and Pharmacodynamic Study of Healthy Chinese Subjects Administered Sodium Zirconium Cyclosilicate (ZS)
• Pharmacokinetic Study of Tacrolimus and Mycophenolate Mofetil in Kidney Transplant Recipients With Hyperkalemia Receiving Patiromer
• Use of Patiromer to Transition Chronic Kidney Disease Patients With Hyperkalemia to a Plant-rich Diet.
• Open-label Safety of Sodium Zirconium Cyclosilicate for up to 12 Months in Japanese Subjects With Hyperkalemia
• ZS Ph2/3 Dose-response Study in Japan
• Pharmacodynamic & Safety of Patiromer in Children & Adolescents (2-<18 Yrs) With Chronic Kidney Disease and Hyperkalemia
• Spironolactone With Patiromer in the Treatment of Resistant Hypertension in Chronic Kidney Disease
• A Study Evaluating the Onset-of-Action, Safety, and Efficacy of RDX227675 for the Treatment of Hyperkalemia
• Relypsa For ED Acute Hyperkalemia Control and Reduction (REDUCE)
• A Study to Investigate the Safety and Efficacy of ZS in Patients With Hyperkalemia
• Patiromer With or Without Food for the Treatment of Hyperkalemia
• Open-label Safety and Efficacy of Sodium Zirconium Cyclosilicate for up to 12 Months
• Open-label Safety & Efficacy of ZS (Sodium Zirconium Cyclosilicate)10g qd to Extend Study ZS-004 in Hyperkalemia.
• Safety & Efficacy of Zirconium Silicate Dosed for 28 Days in Hyperkalemia.
• Efficacy of Sodium Polystyrene Sulfonate in the Treatment of Hyperkaliemia in Pre-dialysis Patients
• An Open-Label, Multiple Dose Study to Evaluate the Pharmacology, Safety, and Tolerability of Patiromer in Participants on Hemodialysis
• Safety and Efficacy of Sodium Polystyrene Sulfonate in Hyperkalemia
• A Two-Part, Single-Blind, Phase 3 Study Evaluating the Efficacy and Safety of Patiromer for the Treatment of Hyperkalemia (OPAL)
• Safety & Efficacy of Zirconium Silicate in Mild to Moderate Hyperkalemia
• Safety & Efficacy of Zirconium Silicate in Chronic Kidney Disease or Moderate Kidney Dysfunction With Mild Hyperkalemia
• Patiromer in the Treatment of Hyperkalemia in Patients With Hypertension and Diabetic Nephropathy (AMETHYST-DN)
• Evaluation of Patiromer in Heart Failure Patients
• Genetic Determinants of the Hypokalemic and Hyperglycemic Effect of Albuterol Inhalation