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Clinical Trials for Muscular Atrophy

• Metformin and Muscle Recovery
• A Placebo-controlled Study of Clenbuterol in Spinal and Bulbar Muscular Atrophy
• A Study Evaluating the Effectiveness and Safety of Risdiplam Administered in Pediatric Patients With Spinal Muscular Atrophy Who Experienced a Plateau or Decline in Function After Gene Therapy
• A Study Evaluating the Effectiveness and Safety of Risdiplam Administered as an Early Intervention in Pediatric Participants With Spinal Muscular Atrophy After Gene Therapy
• A Study to Investigate the Pharmacokinetics and Safety of Risdiplam in Infants With Spinal Muscular Atrophy
• Safety and Efficacy of NMD670 in Ambulatory Adult Patients With Type 3 Spinal Muscular Atrophy
• A Pilot Study Testing Benefits of Ursolic Acid (UA) as a Countermeasure To Myopenia and Insulin Resistance in Chronic Spinal Cord Injury (SCI)
• Long-Term Safety & Efficacy of Apitegromab in Patients With SMA Who Completed Previous Trials of Apitegromab-ONYX
• Withdrawal of Tiratricol Treatment in Males With Monocarboxylate Transporter 8 Deficiency (MCT8 Deficiency)
• Risdiplam in Patients With Spinal Muscular Atrophy Previously Treated With Nusinersen
• A Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Of AJ201 In Patients
• Impacts of Mechanistic Target of Rapamycin (mTOR) Inhibition on Aged Human Muscle (Rapamune)
• A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Taldefgrobep Alfa in Participants With Spinal Muscular Atrophy
• Long-Term Follow-Up Study of Risdiplam in Participants With Spinal Muscular Atrophy (SMA)
• Safety and Tolerability of IMM01-STEM in Patients With Muscle Atrophy Related to Knee Osteoarthritis.
• Phase 3 Active Treatment Trial to Evaluate the Efficacy and Safety of Apitegromab in Patients With Later-Onset Spinal Muscular Atrophy Who Are Being Treated With Nusinersen or Risdiplam
• A Study to Investigate the Safety and Efficacy of RO7204239 in Combination With Risdiplam (RO7034067) in Ambulatory Children With Spinal Muscular Atrophy
• A Study to Evaluate Higher Dose (HD) Nusinersen (BIIB058) in Participants With Spinal Muscular Atrophy Previously Treated With Risdiplam
• Effects of Ketones on Muscle Wasting During Caloric Restriction in Lean Females
• Zoledronic Acid for Prevention of Bone Loss After BAriatric Surgery (ZABAS)
• Extension Study of Nusinersen (BIIB058) in Participants With Spinal Muscular Atrophy Who Previously Participated in a Study With Nusinersen
• Bioavailability and Bioequivalence of Two Risdiplam Tablets in Healthy Participants
• A Clinical Pharmacology Study to Evaluate the Effect of GYM329 on Disuse Muscle Atrophy in Healthy Volunteer
• Study of the Functional Effects of Nusinersen in 5q-spinal Muscular Amyotrophy Adults (SMA Type 2 or 3 Forms)
• A Study of Nusinersen Among Participants With Spinal Muscular Atrophy Who Received Onasemnogene Abeparvovec
• Use of Testosterone to Prevent Post-Surgical Muscle Loss - Pilot Study
• Study of Nusinersen (BIIB058) in Participants With Spinal Muscular Atrophy
• E-CEL UVEC Cells as an Adjunct Cell Therapy for the Arthroscopic Rotator Cuff Repair in Adults
• Pulmonary Function Test Changes and Respiratory Muscle Strength Trends in Spinal Muscular Atrophy Patients Receiving Nusinersen Treatments
• A Drug-drug Interaction Study With Risdiplam Multiple Dose and Midazolam in Healthy Participants
• A Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics and Safety and Tolerability of a Single Oral Dose of Risdiplam Compared to Matched Healthy Participants With Normal Hepatic Function
• Long Term Safety of Amifampridine Phosphate in Spinal Muscular Atrophy 3
• Controlled Trial to Evaluate Amifampridine Phosphate in Spinal Muscular Atrophy Type 3 Patients
• A Study of Risdiplam in Infants With Genetically Diagnosed and Presymptomatic Spinal Muscular Atrophy
• Effects of Total Parenteral Nutrition on Skeletal Muscle Genomics.
• Role of Metformin on Muscle Health of Older Adults
• The Effects of 17β-estradiol on Skeletal Muscle
• Systemic Hormones and Muscle Protein Synthesis
• A Study of Risdiplam (RO7034067) in Adult and Pediatric Participants With Spinal Muscular Atrophy
• SPACE Trial: Pyridostigmine vs Placebo in SMA Types 2, 3 and 4
• Investigate Safety, Tolerability, PK, PD and Efficacy of Risdiplam (RO7034067) in Infants With Type1 Spinal Muscular Atrophy
• A Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of Risdiplam (RO7034067) in Type 2 and 3 Spinal Muscular Atrophy (SMA) Participants
• Effect of Low-Dose Celecoxib on SMN2 in Patients With Spinal Muscular Atrophy
• Expanded Access Program (EAP) for Nusinersen in Participants With Infantile-onset (Consistent With Type 1) Spinal Muscular Atrophy (SMA)
• A Study of CK-2127107 in Patients With Spinal Muscular Atrophy
• A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Risdiplam (RO7034067) Given by Mouth in Healthy Volunteers
• A Study to Evaluate Long Term Safety, Tolerability, and Effectiveness of Olesoxime in Patients With Spinal Muscular Atrophy (SMA)
• A Study for Participants With Spinal Muscular Atrophy (SMA) Who Previously Participated in Nusinersen (ISIS 396443) Investigational Studies.
• LPD+α-ketoacids on Autophagy and Improving Muscle Wasting in CKD
• A Study to Assess the Safety and Tolerability of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy (SMA).
• Evaluation of rGH Therapy to Prevent Muscle Atrophy in Patients With ACL Tears
• Triac Trial II in MCT8 Deficiency Patients
• A Study of Multiple Doses of Nusinersen (ISIS 396443) Delivered to Infants With Genetically Diagnosed and Presymptomatic Spinal Muscular Atrophy
• The Effect of Nandrolone Decanoate and Leucine on Muscle Loss
• A Study to Assess the Efficacy and Safety of Nusinersen (ISIS 396443) in Participants With Later-onset Spinal Muscular Atrophy (SMA)
• An Open Label Study of LMI070 (Branaplam) in Type 1 Spinal Muscular Atrophy (SMA)
• A Study of RO6885247 in Adult and Pediatric Patients With Spinal Muscular Atrophy (MOONFISH)
• Safety and Efficacy Study of Pyridostigmine on Patients With Spinal Muscular Atrophy Type 3
• A Study to Assess the Efficacy and Safety of Nusinersen (ISIS 396443) in Infants With Spinal Muscular Atrophy
• Study of Efficacy and Safety of Bimagrumab in Patients After Hip Fracture Surgery
• Mechanistic Approach to Preventing Atrophy and Restoring Function in Older Adults
• Thyroid Hormone Analog Therapy in MCT8 Deficiency: Triac Trial Patients
• An Open-label Safety and Tolerability Study of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy (SMA) Who Previously Participated in ISIS 396443-CS2 (NCT01703988) or ISIS 396443-CS10 (NCT01780246)
• Safety, Tolerability, and Efficacy of BVS857 in Patients With Spinal and Bulbar Muscular Atrophy
• A Study to Assess the Efficacy, Safety and Pharmacokinetics of Nusinersen (ISIS 396443) in Infants With Spinal Muscular Atrophy (SMA)
• An Open-label Safety and Tolerability Study of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy Who Previously Participated in ISIS 396443-CS1 (NCT01494701)
• An Open-label Safety, Tolerability and Dose-Range Finding Study of Multiple Doses of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy
• Valproate and Levocarnitine in Children With Spinal Muscular Atrophy
• Short and Long Term Treatment With 4-AP in Ambulatory SMA Patients
• Testosterone Administration and ACL Reconstruction in Men
• Safety Study of HPP593 in Subjects During and After Limb Immobilization
• An Open-label Safety, Tolerability, and Dose-range Finding Study of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy (SMA)
• Efficacy and Safety Study of Tesamorelin in Chronic Obstructive Pulmonary Disease (COPD) Subjects With Muscle Wasting
• Study to Assess the Efficacy and Safety of Ibuprofen 50 mg/g Gel Compared to Profenid 25mg/g Gel
• A Study of LY2495655 in Older Participants Undergoing Elective Total Hip Replacement
• Effect of GTx-024 on Muscle Wasting in Patients With Non-Small Cell Lung Cancer (NSCLC) on First Line Platinum
• Phase III Study of the Effect of GTx-024 on Muscle Wasting in Patients With Non-Small Cell Lung Cancer (NSCLC)
• Safety and Efficacy of Olesoxime (TRO19622) in 3-25 Years SMA Patients.
• A Clinical Study to Assess the Effects of SRT2104 Upon Immobilization-Induced Skeletal Muscle Atrophy in Healthy Human Volunteers
• A Clinical Study to Assess the Safety, Tolerability and Pharmacokinetics of Oral SRT2104 Capsules Administered to Healthy Elderly Subjects for 28 Days
• Effect of Goserelin (Zoladex®) in Spinal and Bulbar Muscular Atrophy
• Study to Evaluate the Efficacy of Riluzole in Children and Young Adults With Spinal Muscular Atrophy (SMA)
• CARNIVAL Type I: Valproic Acid and Carnitine in Infants With Spinal Muscular Atrophy (SMA) Type I
• A Pilot Therapeutic Trial Using Hydroxyurea in Type II and Type III Spinal Muscular Atrophy Patients
• A Pilot Therapeutic Trial Using Hydroxyurea in Type I Spinal Muscular Atrophy Patients
• Pilot Study of Growth Hormon to Treat SMA Typ II and III
• Study to Evaluate Sodium Phenylbutyrate in Pre-symptomatic Infants With Spinal Muscular Atrophy
• A Trial of Hydroxyurea in Spinal Muscular Atrophy
• Valproic Acid in Ambulant Adults With Spinal Muscular Atrophy
• 5-Alpha Reductase and Anabolic Effects of Testosterone
• Study of GTx-024 on Muscle Wasting (Cachexia) Cancer.
• Clinical Trial of Sodium Phenylbutyrate in Children With Spinal Muscular Atrophy Types II or III
• Clinical Trial of Sodium Phenylbutyrate in Children With Spinal Muscular Atrophy Type I
• Study of Safety and Dosing Effect on SMN Levels of Valproic Acid (VPA) in Patients With Spinal Muscular Atrophy
• Dutasteride to Treat Spinal and Bulbar Muscular Atrophy (SBMA)
• Effects of Growth Hormone in Chronically Ill Children
• Valproic Acid and Carnitine in Patients With Spinal Muscular Atrophy
• Physiologic Effects of PRMS & Testosterone in the Debilitated Elderly
• Phase II Study of Leuprolide and Testosterone for Men With Kennedy's Disease or Other Motor Neuron Disease