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Clinical Trials for Pick Disease of the Brain

• Lemborexant for Insomnia in a Patient With Dementia: An N-of-1 Trial
• Propranolol in Primary Progressive Aphasia
• Phase 2 Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Oral AZ-3102 in Patients With GM2 Gangliosidosis or Niemann-Pick Type C Disease
• Nabilone for Agitation in Frontotemporal Dementia
• Open-label Extension (OLE) Study of WVE-004 in Patients With C9orf72-associated Amyotrophic Lateral Sclerosis (ALS) and/or Frontotemporal Dementia (FTD)
• The Safety and The Efficacy Evaluation of ET-STEM in Patients With Frontotemporal Dementia
• A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL593 in Healthy Participants and Participants With Frontotemporal Dementia (FTD-GRN)
• Veri-T: A Trial of Verdiperstat in Patients With svPPA Due to TDP-43 Pathology
• A Pivotal Study of N-Acetyl-L-Leucine on Niemann-Pick Disease Type C
• A Phase 2a Study of TPN-101 in Patients With C9ORF72 ALS/FTD
• Adrabetadex to Treat Niemann-Pick Type C1 (NPC1) Disease
• Dopaminergic Therapy for Frontotemporal Dementia Patients
• Study of WVE-004 in Patients With C9orf72-associated Amyotrophic Lateral Sclerosis (ALS) or Frontotemporal Dementia (FTD)
• Phase 3 Study to Evaluate Intravenous Trappsol(R) Cyclo(TM) in Pediatric and Adult Patients With Niemann-Pick Disease Type C1
• A Study of PBFT02 in Patients With Frontotemporal Dementia and Progranulin Mutations (FTD-GRN)
• Phase 1/2 Clinical Trial of PR006 in Patients With Frontotemporal Dementia With Progranulin Mutations (FTD-GRN)
• A Phase 3 Study to Evaluate Efficacy and Safety of AL001 in Frontotemporal Dementia (INFRONT-3)
• The Influence of Vascular Burden, Amyloid Plaque and Tau Protein in Patients With Vascular Cognitive Impairment and Dementia With Tauopathy
• Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD
• Intranasal Insulin in Frontotemporal Dementia (FTD)
• A Phase 2 Study to Evaluate Safety of Long-term AL001 Dosing in Frontotemporal Dementia (FTD) Patients (INFRONT-2)
• Safety and Efficacy of Miglustat in Chinese NPC Patients
• Open-Label Study of Long-Term Safety and Efficacy of Intravenous Trappsol Cyclo (HPβCD) in Niemann-Pick Disease Type C
• Combined Intrathecal and Intravenous VTS-270 Therapy for Liver and Neurological Disease Associated With Niemann-Pick Disease, Type C1
• Open-label Study of VTS-270 in Participants With Neurologic Manifestations of Niemann-Pick Type C1
• N-Acetyl-L-Leucine for Niemann-Pick Disease, Type C (NPC)
• Safety and Tolerability Study of VTS-270 in Pediatric Participants With Niemann-Pick Type C (NPC) Disease
• BIIB092 in Primary Tauopathies: CBS, nfvPPA, sMAPT, and TES
• 18F-PM-PBB3 PET Study in Tauopathy Including Alzheimer's Disease, Other Dementias and Normal Controls
• Evaluation of [18F]PI-2620 as a Potential Positron Emission Computed Tomography Radioligand for Imaging Tau Protein in the Brain
• Study of IV VTS-270 for Infantile Liver Disease Associated With Niemann-Pick Disease, Type C
• Tau PET Imaging in Atypical Dementias
• Intranasal Oxytocin for Frontotemporal Dementia
• Study of Lithium Carbonate to Treat Niemann-Pick Type C1 Disease
• A 24-month Phase 1 Pilot Study of AADvac1 in Patients With Non Fluent Primary Progressive Aphasia
• Flortaucipir PET Imaging in Subjects With FTD
• Study of the Pharmacokinetics of Trappsol and Effects on Potential Biomarkers of Niemann-Pick C1 (NPC1)
• Safety and Efficacy of Intravenous Trappsol Cyclo (HPBCD) in Niemann-Pick Type C Patients
• Low-Dose Lithium for the Treatment of Behavioral Symptoms in Frontotemporal Dementia
• Assessment of Hyperphosphorylated Tau PET Binding in Primary Progressive Aphasia
• F 18 T807 Tau PET Imaging of Frontotemporal Dementia (FTD)
• Tau PET Imaging With 18F-AV-1451 in Subjects With MAPT Mutations
• Arimoclomol Prospective Study in Patients Diagnosed With NiemannPick Disease Type C
• VTS-270 to Treat Niemann-Pick Type C1 (NPC1) Disease
• Open-Label Study of Leuco-methylthioninium Bis(Hydromethanesulfonate) (LMTM) in Subjects With Alzheimer's Disease or Behavioral Variant Frontotemporal Dementia (bvFTD)
• Study to Assess the Safety, Tolerability, and Pharmacodynamic (PD) Effects of FRM-0334 in Subjects With Prodromal to Moderate Frontotemporal Dementia With Granulin Mutation
• Phase 1/2 Study of Vorinostat Therapy in Niemann-Pick Disease, Type C1
• Evaluation of [18F]MNI-777 PET as a Marker of Tau Pathology in Subjects With Tauopathies Compared to Healthy Subjects
• Impact of Emotional Mimicry and Oxytocin on Frontotemporal Dementia
• Imaging Characteristics of Florbetapir 18F in Patients With Frontotemporal Dementia, Alzheimer's Disease and Normal Controls.
• Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech
• Application of Miglustat in Patients With Niemann-Pick Type C
• Hydroxypropyl Beta Cyclodextrin for Niemann-Pick Type C1 Disease
• Amyloid-related Imaging Abnormalities (Microbleeds) in Atypical AD
• Safety and Efficacy Study Evaluating TRx0237 in Subjects With Behavioral Variant Frontotemporal Dementia (bvFTD)
• PiB PET Scanning in Speech and Language Based Dementias
• Human Placental-Derived Stem Cell Transplantation
• Safety Study of Intranasal Oxytocin in Frontotemporal Dementia
• Davunetide (AL-108) in Predicted Tauopathies - Pilot Study
• Oxytocin and Social Cognition in Frontotemporal Dementia
• Biomarker Validation for Niemann-Pick Disease, Type C: Safety and Efficacy of N-Acetyl Cysteine
• Imaging of Brain Amyloid Plaques in the Aging Population
• Hematopoietic Stem Cell Transplantation (HCT) for Inborn Errors of Metabolism
• Effects of Tolcapone on Frontotemporal Dementia
• Open Label Pilot Study of the Effects of Memantine on FDG-PET in Frontotemporal Dementia
• Memantine (10mg BID) for the Frontal and Temporal Subtypes of Frontotemporal Dementia
• A Pilot Study to Explore the Safety and Tolerability of Galantamine HBr in the Treatment of Pick Complex/Frontotemporal Dementia
• Safety Study of rhASM Enzyme Replacement Therapy in Adults With Acid Sphingomyelinase Deficiency (Niemann-Pick Disease)
• Serotonergic Function and Behavioural and Psychological Symptoms of Frontotemporal Dementia
• Saccadic Eye Movements in Patients With Niemann-Pick Type C Disease
• Efficacy and Tolerability of Memantine in Frontotemporal Dementia (FTD) Patients
• Stem Cell Transplant for Inborn Errors of Metabolism
• Amantadine for the Treatment of Behavioral Disturbance in Frontotemporal Dementia (FTD)
• PET Scan of Brain Metabolism in Relation to Age and Disease