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Clinical Trials for Hepatic Insufficiency

• Study of Pirtobrutinib (LOXO-305) in Participants With Impaired Liver Function and Healthy Participants
• Phase 1 Hepatic Insufficiency Trial of Methoxyethyl Etomidate Hydrochloride
• A Study of LY3437943 in Participants With Impaired and Normal Liver Function
• Efficacy, Safety and Tolerability of VS-01 in Adult Patients With Acute-on-Chronic Liver Failure and Ascites (UNVEIL-IT)™
• A Study of LY3502970 in Participants With Impaired and Normal Liver Function
• The Efficacy and Safety of Rifaximin Treatment
• Efficacy of L-ornithine L-aspartate and Therapeutic Plasma Exchange Versus Plasma Exchange Alone in Lowering Ammonia and Improving Outcomes in Pediatric Acute Liver Failure.
• A Study to Test How Iclepertin is Taken up in the Blood of People With and Without Liver Problems
• Pharmacokinetic Characteristics, Safety, and Tolerability in Subjects With Mild or Moderate Liver Insufficiency and Healthy Subjects
• Intravenous BCAA for HE in ACLF (BCAA-HE-ACLF)
• F573 for Injection for the Treatment of Liver Injury/Failure
• A Study to Test How BI 1015550 is Taken up in the Blood of People With and Without Liver Problems
• Pharmacokinetic Study of Continuous Infusion of Remazolam in Mechanically Ventilated Patients in ICU
• A Study of Imlunestrant (LY3484356) in Female Participants With Impaired Liver Function
• Efficacy and Safety of Avatrombopag for Treating TCP in HBV-ACLF Patients Receiving ALSS Treatment
• A Study to Evaluate CC-486 in Participants With Moderate or Severe Hepatic Impairment Compared With Normal Hepatic Function in Cancer Participants
• Acute Hemodynamic Response to Carvedilol in Predicting Survival in Acute on Chronic Liver Failure Patients - A Pilot Study.
• MK-8507 in Participants With Mild or Moderate Hepatic Impairment (MK-8507-014)
• Intravenous NAC Use in ACLF Patients
• Pharmacokinetics Of Jaktinib In Subjects With Hepatic Impairment And Normal Hepatic Function
• A Study to Evaluate the Effect of Hepatic Insufficiency on the Pharmacokinetics (PK) of ACP-196
• TReatment for ImmUne Mediated PathopHysiology
• TAK-242 in Patients With Acute Alcoholic Hepatitis
• Pharmacokinetic Study of Icenticaftor in Participants With Hepatic Impairment
• Efficacy of Early Terlipressin Plus Albumin Therapy in Comparison to Standard Treatment for HRS-AKI in Acute-on-chronic Liver Failure.
• Use of HA 330-II for Hemofiltration in Patients With ALF as a Bridge to Liver Transplantation .
• Intravenous Branched Chain Amino Acids for Hepatic Encephalopathy in ACLF
• Study to Evaluate the Efficacy and Safety of HepaStem in Patients With Acute on Chronic Liver Failure (ACLF)
• A Study to Investigate the Effect of Impaired Hepatic Function on the Pharmacokinetics of Entrectinib in Volunteers With Different Levels of Hepatic Function
• The Effect of Terlipressin on Recovery of Liver Function After Hepatectomy
• Plasma Exchange in Acute on Chronic Liver Failure
• Efficacy and Safety of Hemoperfusion or Plasma Exchange Compared to Standard Medical Therapy in Patients With Acute on Chronic Liver Failure
• PEG3350 in ACLF With Hepatic Encephalopathy
• Investigate the Influence of Severe Hepatic Impairment on the Pharmacokinetics of Acalabrutinib and Its Metabolite
• A Study of Tirzepatide in Participants With Impaired Liver Function
• Three Types of Nucleotide/Nucleoside Analogues Treatment in HBV Related ACLF
• Branched-chain Amino Acid Supplementation for Hepatocellular Carcinoma
• A Study to Test How Different Doses of BI 685509 Are Tolerated in Patients With Liver Problems
• TRimetazidine for acUte on Chronic Liver Failure STudy
• The Efficacy and Safety of Nucleos(t)Ide Analogues in the Treatment of HBV-related Acute-on-chronic Liver Failure
• Study on the Optimal Strategy for Acute-on-chronic Liver Failure With Integrative Treatment
• An Investigational Study of Experimental Medication BMS-986231 Given in Participants With Different Levels of Liver Function
• Safety and Pharmacokinetics of Zanubrutinib (BGB-3111) in Healthy Subjects and Those With Impaired Liver Function
• To Assess the Role of Fecal Microbiota Transplant in Acute Liver Failure
• A Study of Ipatasertib in Participants With Mild, Moderate or Severe Hepatic Impairment Compared to Healthy Participants
• Clinical Pharmacology of FYU-981 (Subjects With Hepatic Insufficiency)
• Single-Dose Pharmacokinetics of MK-3866 in Participants With Hepatic Impairment (MK-3866-006)
• Study to Investigate the Influence of Hepatic Insufficiency on the Pharmacokinetics of Tozadenant
• Study of Copanlisib in Hepatic or Renal Impairment
• To Assess the Efficacy of High-Volume Plasma Exchange and GCSF Versus GCSF Alone in Patients of Acute on Chronic Liver Failure (ACLF).
• The Efficacy and Safety of Thymosin-α1 in Patients With HBV-related ACLF
• An Open-Label Study Investigating MK-8931 in Participants With Mild and Moderate Hepatic Insufficiency (MK-8931-016)
• Effect of Hepatic and Renal Impairment on the Pharmacokinetics, Safety and Tolerability of BAY1841788 (ODM-201)
• The Effect of Somatostatin for Treatment of Post Hepatectomy Liver Failure (PHLF)
• Transfer Factor Efficacy in the Management of Cirrhosis-associated Immune Dysfunction
• Major Liver Resection: Early Clotting Disorders and Functional Impairment.
• UC-MSC Infusion for HBV-Related Acute-on-Chronic Liver Failure
• To Study the Influence of GCSF on Natural History of Acute On Chronic Liver Failure After the Acute Phase
• 13C-Methacetin Breath Test for the Prediction of Outcome in in ALI or ALF
• High Volume Plasma Exchange in Children With Acute Liver Failure and Acute on Chronic Liver Failure
• High-Volume Plasma Exchange Versus Standard Medical Treatment in Patients With Acute Liver Failure
• To Study the Immunomodulating Effects and Safety Profile of ω3 and ω6 PUFA Containing Intravenous Lipid Emulsion in Patients With Acute on Chronic Liver Failure
• Randomized Controlled Trial Comparing the Efficacy and Safety of FMT in Hepatitis B Reactivation Leads to Acute on Chronic Liver Failure.
• Study to Evaluate a Dose of Telotristat Etiprate in Male and Female With Mild, Moderate and Severe Hepatic Insufficiency and Matched Healthy Subjects
• Granulocyte Colony Stimulating Factor (G-CSF) to Treat Acute-on-chronic Liver Failure
• A Study of the Pharmacokinetics of Uprifosbuvir (MK-3682) and Ruzasvir (MK-8408) in Participants With Moderate and Severe Hepatic Insufficiency (MK-3682-029)
• Efficacy of Nonselective Beta Blocker vs Placebo in Patients With Acute-on-chronic Liver Failure With Small/ no Esophageal Varices
• To Compare the Response Rate of Noradrenaline vs. Terlipressin in Hepatorenal Syndrome in Patients With Acute on Chronic Liver Failure
• Cardiox Liver Function Test Pivotal Trial
• Liver Function Assessment - Feasibility and Dosing Study
• Incidence And Outcome Of Paracentesis Induced Circulatory Dysfunction In Acute-On-Chronic Liver Failure.
• Pharmacokinetics of Imrecoxib in Subjects With Hepatic Insufficiency
• A Study of Abemaciclib in Participants With Varying Degrees of Liver Impairment
• Steroids in Fulminant Hepatitis A in the Pediatric Age Group
• A Study To Describe The Effect Of Impaired Hepatic Function Of The Pharmacokinetics Of Palbociclib
• RCT Study on Granulocyte Colony-stimulating Factor(G-CSF) Treatment of Hepatic Failure
• Effect of Goal Directed Ammonia Lowering Therapy in Acute on Chronic Liver Failure Patients With Hepatic Encephalopathy.
• Pharmacokinetics, Safety and Tolerability of BIIL 284 BS in Patients With Hepatic Impairment in Comparison to Healthy Volunteers
• Pharmacokinetics (PK) of Tipranavir/Ritonavir, Ribavirin, Pegylated Interferon (Peg INF) in Hepatitis C (HCV) Subjects With Mild Hepatic Impairment and in HCV, Hepatitis B (HBV), Hepatitis D Infected Subjects or Alcoholic Cirrhosis With Moderate Hep
• Study to Determine the Pharmacokinetics on TPV/r in Subjects With Mild and Moderate Hepatic Insufficiency
• Nintedanib in Volunteers With Hepatic Impairment Compared With Healthy Volunteers
• Study to Evaluate the Effects of Underlying Renal or Hepatic Dysfunction on the Pharmacokinetics of Nevirapine
• Pharmacokinetics and Pharmacodynamics of BI 1356 in Subjects With Different Degrees of Liver Impairment as Compared to Healthy Subjects
• Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Dabigatran Etexilate in Patients With Moderate Hepatic Impairment Compared to Subjects With Normal Hepatic Function
• A Study to Investigate the Exposure and Safety and Tolerability of a Single Dose of FG-4592 in Subjects With Moderately Diminished Liver Function Compared to Those With Normal Liver Function
• Phase 1 Study of Multiple-Dose Pharmacokinetics of Cenicriviroc in Subjects With Mild and Moderate Hepatic Impairment
• Study of Efficacy and Safety of Grazoprevir (MK-5172) + Elbasvir (MK-8742) in Chronic Hepatitis C Participants With Child-Pugh (CP)-B Hepatic Insufficiency (MK-5172-059)
• A Study to Investigate the Influence of Hepatic Insufficiency on the Pharmacokinetics of Doravirine (MK-1439) (MK-1439-019)
• Icotinib in Advanced Non-small Cell Lung Cancer (NSCLC) With Hepatic Insufficiency
• Pharmacokinetic and Pharmacodynamic Study of IDN-6556 in ACLF
• Safety, Tolerability, and Pharmacokinetics of a Single Dose of NBI-98854 in Subjects With Mild,Moderate, or Severe Hepatic Insufficiency
• Single Dose of 9-cis-retinoic Acid in Hepatic Patients
• A Pharmacokinetic Study of Baricitinib in Participants With Liver Disease
• Evaluate the Pharmacokinetics, Safety, and Tolerability of Alisporivir in Subjects With Hepatic Impairment Compared to Healthy Subjects
• Single Dose Pharmacokinetics of Suboxone Study in Hepatic Impaired Subjects
• Safety and Efficacy of Diverse Mesenchymal Stem Cells Transplantation for Liver Failure
• A Study of Evacetrapib (LY2484595) in Participants With Hepatic (Liver) Impairment
• The Influence of Hepatic Insufficiency on the Pharmacokinetics of Elbasvir (MK-8742) (MK-8742-009)
• An Open-label, Non-randomized, Parallel Group Study in Subjects With Mild and Moderate Hepatic Insufficiency and Healthy Volunteers
• A Single Dose Study of LY2605541 in Participants With Liver Impairment
• A Single-Dose Study of the Pharmacokinetics of Vibegron (MK-4618) in Adults With Hepatic Insufficiency (MK-4618-013)
• Methylprednisolone N Acetylcysteine in Hepatic Resections
• A Trial of Ribavirin in Patients With ACLF Due to Hepatitis E Virus
• Ulinastatin Preventing Postoperative Hepatic Failure in Hepatocellular Carcinoma (HCC)
• Emergency Use of OCR-002 in Acute Liver Failure (ALF)
• Safety Study of Ornithine Phenylacetate to Treat Patients With Acute Liver Failure/Severe Acute Liver Injury
• Assessment of Pharmacokinetics of Single Dose Odanacatib (MK-0822) in Participants With Moderate Hepatic Insufficiency (MK-0822-070)
• A Study of LY2140023 in Hepatically-Impaired Participants
• Registry Protocol for Tracking Trial Subjects After VTI-206 Study Completion
• Use of N-Acetylcysteine During Liver Procurement
• Study to Investigate the Influence of Hepatic Insufficiency on the Pharmacokinetics of Grazoprevir (MK-5172-013)
• Efficacy of Granulocyte Colony-stimulating Factor and Erythropoetin for Patients With Acute-on-chronic Liver Failure
• Hepatocyte Transplantation for Acute Decompensated Liver Failure
• A Study Evaluating the Efficacy of Glucocorticoids in Patients With Pre-ACLF-HBV
• Granulocyte Colony Stimulating Factor (G-CSF) in Acute Liver Failure and Alcoholic Hepatitis
• Efficacy & Safety of ALF-5755 in Patients With Nonacetaminophen Severe Acute Hepatitis & Early Stage Acute Liver Failure
• A Pharmacokinetic Study of Trabectedin in Patients With Advanced Malignancies and Hepatic Dysfunction
• Pharmacokinetics of 9-cis-retinoic Acid (Alitretinoin, Toctino®) in Patients With Hepatic Disease
• The Efficacy and Safety of Entecavir Treatment of Patients With Acute on Chronic Hepatitis B Liver Failure
• Allogenic Bone Marrow Stem Cell Transplantation in Liver Failure
• Safety and Efficacy of Human Mesenchymal Stem Cells for Treatment of Liver Failure
• A Study of Canagliflozin in Study Participants With Various Degrees of Impaired Hepatic (Liver) Function
• Acetaminophen in Combination With N-Acetylcysteine (NAC) Versus Placebo in Treating Fever
• Pharmacokinetics of Anacetrapib (MK0859) in Patients With Hepatic Insufficiency (MK-0859-039)
• Pharmacokinetics of Empagliflozin (BI 10773) in Patients With Impaired Liver Function
• Randomized Controlled Trial of Tenofovir in Patients of Reactivation of Hepatitis B Presenting as Acute on Chronic Liver Failure
• Pharmacokinetics of Suvorexant in Participants With Hepatic Insufficiency (MK-4305-017)
• Ridaforolimus in Patients With Hepatic Insufficiency (MK-8669-046)
• Hepatic Impaired Subjects Compared to Healthy Subjects Receiving Multi-dose BMS-650032
• A Study Investigating the Influence of Hepatic Insufficiency on the Pharmacokinetics of Vaniprevir (MK-7009-005)
• A Safety and Tolerability Study of CP-690,550 in Subjects With Hepatic Impairment and Normal Hepatic Function
• Pharmacokinetics of Everolimus in Subjects With Hepatic Insufficiency
• Intravenous Milk Thistle (Silibinin-Legalon) for Hepatic Failure Induced by Amatoxin/Amanita Mushroom Poisoning
• Study of N-Acetylcysteine in Acute Liver Failure (ALF)
• Single-Dose Pharmacokinetics of BMS-790052 in Participants With Hepatic Impairment
• Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Dimebon [Pf-01913539] In Subjects With Hepatic Impairment And Normal Hepatic Function
• Open-Label, Single-Dose Study to Evaluate the Safety and PK of DIC075V in Subjects With Renal Insufficiency and Hepatic Impairment Compared to Healthy Subjects and Evaluate the Safety and Pharmacokinetics of HPβCD When Administered in DIC075V Compa
• Study Evaluating The PK And Safety Of Neratinib In Healthy Subjects And Subjects With Chronic Liver Disease
• A Study of MK0431 in Patients WIth Hepatic Insufficiency (0431-017)(COMPLETED)
• Evaluation Of Hepatic Impairment On AG-013736 Pharmacokinetics
• Study Examining The Effect Of Hepatic Impairment On Safety, Toleration And How The Body Processes An Experimental Drug
• Study of Telaprevir in Subjects With Hepatic Impairment
• Therapeutic Efficacy of L-Ornithine L-Aspartate Infusion in Patients With Acute Liver Failure
• Safety and Pharmacokinetics of Indacaterol in Healthy Subjects and Those With Impaired Liver Function
• A Study Of GW406381 In Volunteers With Moderate Hepatic Impairment
• Study Evaluating the Safety of HCV-796 in Subjects With Liver Disease and in Healthy Adults
• N-acetylcysteine in Non-Acetaminophen Pediatric Acute Liver Failure
• Phase I/II Study of Recombinant Human Hepatocyte Growth Factor in Fulminant Hepatic Failure
• Clinical Trial of Pentoxifylline in Patient With Cirrhosis
• A Pharmacokinetic Study to Assess Nevirapine [Viramune] Levels in HIV Infected Patients With Impaired Hepatic Functions
• Randomized Study of Acetylcysteine in Patients With Acute Liver Failure Not Caused by Acetaminophen