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Clinical Trials for Acidosis

• 0.9% Saline Versus Balanced Solutions in Severe Diabetic Ketoacidosis
• Balanced Multi-Electrolyte Solution Versus Saline Trial for Diabetic KetoAcidosis
• SODium BICarbonate for Metabolic Acidosis in the ICU
• Comparison of a Low Dose to a Standard Dose of Insulin in Adult DKA in ICU to Reduce Metabolic Complications
• Effect of Flow Rate and pH on Muscle Acidosis
• Meglimine Sodium Succinate for Correction of Metabolic Acidosis in Critically Ill Patients
• Reducing Dietary Acid With Food Versus Oral Alkali in People With Chronic Kidney Disease (ReDACKD)
• Effect of Alkali Therapy on Vascular and Graft Function in Kidney Transplant Recipients
• Randomized Trial of Veverimer on Muscle Mitochondrial Energetics and Physical Endurance in Persons With CKD
• A First in Human, Dose Escalation Study to Evaluate the Safety and Tolerability of BBP-671 in Healthy Volunteers and Patients With Propionic Acidemia or Methylmalonic Acidemia
• Metformin in Diabetic Patients Undergoing Coronary Angiography
• Study of HST5040 in Subjects With Propionic or Methylmalonic Acidemia
• Study of the Effect of SZC on Serum Potassium and Serum Bicarbonate in Patients With Hyperkalemia and Metabolic Acidosis Associated With Chronic Kidney Disease
• The KHENEREXT Study
• Bicarbonate Administration and Cognitive Function in Midlife and Older Adults With CKD
• Early Basal Insulin Administration in Adult Diabetic Ketoacidosis Management
• Long-term Efficacy of Carglumic Acid in Organic Acidemia.
• The Causal Connection Between Sng and Muscle Acidosis
• Sodium Bicarbonate for the Treatment of Severe Metabolic Acidosis With Moderate or Severe Acute Kidney Injury in ICU
• High Versus Low Bicarbonate Bath in Critically-ill Patients Receiving Continuous Renal Replacement Therapy
• Extension Study in Primary Distal Renal Tubular Acidosis
• Thiamine as Adjunctive Therapy for Diabetic Ketoacidosis
• Evaluation of Effect of TRC101 on Progression of Chronic Kidney Disease in Subjects With Metabolic Acidosis
• Study Evaluating Subjects With Distal Renal Tubular Acidosis
• Balanced Solutions and Plasma Electrolytes
• Alcohol: Thiamine and or Magnesium 1
• Bicarbonate Administration in Kidney Transplant Recipients
• Long-term Safety Extension to Study TRCA-301
• Evaluation of TRC101 in Subjects With Metabolic Acidosis Associated With Chronic Kidney Disease
• Thiamine Supplementation in Patients With Septic Shock
• Preserve-Transplant Study
• Double Blinded Randomized Control Trial of Types of IVF in Children With DKA
• Alkalinization by Urologists & Nephrologists
• Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest
• Early Subcutaneous Insulin Glargine Plus Standard of Care for Treatment of Diabetic Ketoacidosis
• Bicarbonate Administration in CKD
• Evaluation of TRC101 in Subjects With Chronic Kidney Disease and Metabolic Acidosis
• Early Administration of Long-acting Insulin Treatment of Diabetic Ketoacidosis in Pediatric Type 1 Diabetes
• Sodium Bicarbonate to Treat Severe Acidosis in the Critically Ill
• Carglumic Acid in Methylmalonic Acidemia and Propionic Acidemia
• Bicarbonate in Patients With Out-of-hospital Cardiac Arrest
• Metabolic Acidosis and Vascular Function in Patients With Chronic Kidney Disease
• Effectiveness of Subcutaneous Glargine On The Time To Closure of The Anion Gap in Patients Presenting to the Emergency Department With Diabetic Keto-acidosis
• Phase 2c Dose Comparison Study of MP4OX in Trauma
• Nitroglycerin Infusion During Cardiac Surgery
• Efficacy, Safety Study and Benefit of Alkali Therapy in Sickle Cell Disease
• Safety of Continuing Metformin in Diabetic Patients With Normal Kidney Function Receiving Contrast Media
• Dichloroacetate Treatment of Congenital Lactic Acidosis Phase B: Expanded Access
• Influence of Polymorphisms in the ATP6V1 Gene of the V-ATPase on the Development of Incomplete Distal Renal Tubular Acidosis
• Short-Term Outcome of N-Carbamylglutamate in the Treatment of Acute Hyperammonemia
• Long-term Outcome of N-Carbamylglutamate Treatment in Propionic Acidemia and Methylmalonic Acidemia
• Ringer's Lactate Versus Normal Saline in Caesarean Section
• Preoperative Parenteral Thiamine Supplementation in Patients Undergoing Heart Surgery
• Anti-IL-1 Treatment in Children Diabetic Keto-Acidosis (DKA) at Diagnosis of Type 1 Diabetes
• Compassionate Use of Triheptanoin (C7) for Inherited Disorders of Energy Metabolism
• Alkali Therapy in Chronic Kidney Disease
• Randomized Control Trial of Fluid Therapy for Pediatric Diabetic Ketoacidosis
• Lactic Acidosis During Entecavir(ETV)Treatment
• Increasing Ureagenesis in Inborn Errors of Metabolism With N-Carbamylglutamate
• Effect of Propofol and Sevoflurane on Lactate During Anesthesia for Pediatric Heart Catheterisation
• Phase IIb Study of MP4OX in Traumatic Hemorrhagic Shock Patients
• Study of Blood Lactate Levels in Patients Treated With Antipsychotics
• Phase IIa Study of MP4OX in Traumatic Hemorrhagic Shock Patients
• Subcutaneous Aspart Insulin to Treat Diabetic Ketoacidosis (DKA) and Beta-Hydroxybutyrate Testing in DKA
• Metabolic Acidosis in Renal Transplant Patients
• Intraoperative Fluid Management in Laparoscopic Bariatric Surgery
• Study of Idebenone in the Treatment of Mitochondrial Encephalopathy Lactic Acidosis & Stroke-like Episodes
• Pharmacotoxicology of Trichloroethylene Metabolites
• Anaplerotic Therapy in Propionic Acidemia
• Basal Insulin in the Management of Patients With Diabetic Ketoacidosis (DKA)
• Lactate Metabolism Study in HIV Infected Persons
• Use of Insulin Glargine to Treat Diabetic Ketoacidosis
• D4T or Abacavir Plus Vitamin Enhancement in HIV-Infected Patients (DAVE)
• Inhaled Nitric Oxide in Neonates With Elevated A-a DO2 Gradients Not Requiring Mechanical Ventilation
• Prevention of Dichloroacetate Toxicity
• Dichloroacetate Kinetics, Metabolism and Toxicology
• Phase II Pilot Randomized Study of Sodium Dichloroacetate in Patients With Congenital Lactic Acidemia
• Phase III Randomized Study of Sodium Dichloroacetate in Children With Congenital Lactic Acidosis