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Clinical Trials for Congenital Abnormalities

• Efficacy of Topical 95% TCA in the Treatment of CIN 1 or Less After Low-grade Abnormality of Screening Test
• Use of Cinnamomum Verum for Induction of Labor. Double Blind Randomized Clinical Trial
• Laminaria Tents Versus Vaginal Prostaglandin in Cervical Ripening
• Pilot Study on Trametinib for Surgical Unruptured AVMs
• Hemorrhagic Brainstem Cavernous Malformations Treatment With Sirolimus: a Single Centre, Randomised, Placebo-controlled Trial
• Effectiveness of CRD-4730 in Participants With Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
• Alpelisib in Pediatric and Adult Patients With Lymphatic Malformations Associated With a PIK3CA Mutation.
• A Study of X-VRD Combined With CART-ASCT-CART2 Treatment in NDMM Patients With P53 Abnormalities
• Periocular Rejuvenation by Topical Hyaluronic Acid Nano Particles
• MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies
• The Effects of Ferric Derisomaltose on Postoperative Anemia in Spinal Deformity Surgery
• Semaglutide Improves Metabolic Abnormalities and Fertility in Obese Infertile Women With Polycystic Ovary Syndrome
• Guanfacine Extended Release for the Reduction of Aggression and Self-injurious Behavior Associated With Prader-Willi Syndrome
• Assessment of the Efficacy and Safety of Alpelisib (BYL719) in Pediatric and Adult Patients With Megalencephaly-CApillary Malformation Polymicrogyria Syndrome (MCAP)
• Observation vs Progesterone Treatment for Management of Uterine Arteriovenous Malformation
• DEX vs SEVO in Congenital Heart Surgery
• CEM to Reduce Biopsy Rates for Less Than Highly Suspicious Breast Abnormalities: a Prospective Study
• Cobimetinib In Extracranial Arteriovenous Malformations (COBI-AVM Study)
• A Study to Examine the Effects of the Leptin Receptor (LEPR) Agonist Antibody REGN4461 in Adult Patients With Familial Partial Lipodystrophy (FPLD)
• The Symptomatic Cerebral Cavernous Malformation Trial of REC-994
• Study Evaluating the Safety and Efficacy of PTX-022 (QTORIN Sirolimus) in the Treatment of Microcystic Lymphatic Malformations
• A New Approach in Laser Surgery Using the Regenerative Solution in Children Diagnosed With Vascular Pathology
• Use of the Cardioprotectant Dexrazoxane During Congenital Heart Surgery
• A Pharmacokinetic, Pharmacodynamic, Safety and Tolerability Study of CERC-006 in Adults With Complex Lymphatic Malformations
• Percutaneous Administration of Sirolimus in the Treatment of Superficial Complicated Vascular Anomalies
• Weekly Sirolimus Therapy
• Ultrasound Guided Infraclavicular Brachial Plexus Block Using Levo-bupivacaine Alone or Combined With Dexmedetomidine for Hand and Forearm Surgeries
• Study of RET Inhibitor TAS0953/HM06 in Patients With Advanced Solid Tumors With RET Gene Abnormalities
• Efficacy and Safety of Rapamycin to Complex Vascular Anomalies in Pediatric Patients
• Clonidine for Tourniquet-related Pain in Children
• First in Human Trial of Topical VT30 in Pts With Venous/Lymphatic Malformations Assoc With PIK3CA or TEK Gene Mutations
• Contribution of Dolutegravir to Obesity and Cardiovascular Disease
• Lovastatin for Treatment of Brain Arteriovenous Malformations
• Trametinib in the Treatment of Complicated Extracranial Arterial Venous Malformation
• Comparative Study for Incidence of Proximal Junctional Kyphosis Between Parathyroid Hormone and Denosumab Following Adult Spinal Deformity Surgery : A Prospective, Randomized Controlled Trial
• Topical Rapamycin/Sirolimus for Complicated Vascular Anomalies and Other Susceptible Lesions
• Effects of Restylane-L® Filler Injection for Non-Surgical Rhinoplasty
• TOPical Sirolimus in linGUal Microcystic Lymphatic Malformation -TOPGUN
• Effect of Tafoxiparin on Cervical Ripening and Induction of Labor in Term Pregnant Women With an Unripe Cervix
• Treatment of Congenital Vascular Malformations Using Sirolimus: Improving Quality of Life
• Topical Sirolimus in Cutaneous Lymphatic Malformations
• Efficacy of Rapamycin (Sirolimus) in the Treatment of BRBNS, Hereditary or Sporadic Venous Malformation
• Serial Amnioinfusions as Regenerative Therapy for Pulmonary Hypoplasia
• Comparison of Misoprostol Ripening Efficacy With Dilapan
• Evaluation of Trigeminal Nerve Blockade
• Treat_CCM: Propranolol in Familial Cerebral Cavernous Malformation
• Efficacy and Safety of Sirolimus to Vascular Anomalies
• Long Term Effects on Skin Hyper Pigmentation With and Without Mesenchymal Stem Cell Enriched Adipose Tissue Grafting for "Contour Deformities With Pigmentary Changes on Face"
• Tranexamic Acid in Adult Spinal Deformity Surgery
• Oral Propanolol for Surgically Inaccessible Cavernous Malformations
• Tenofovir Disoproxil Fumarate in Combination of Hepatitis B Vaccine for Preventing Hepatitis B Vertical Transmission
• Effect of Oral Propranolol on mRNA Expresssion in Symptomatic Cavernous Malformation
• Integrated Management of Pronation Deformity in Cerebral Palsy
• OK432 (Picibanil) in the Treatment of Lymphatic Malformations
• A Study of TAS0728 in Patients With Solid Tumors With HER2 or HER3 Abnormalities
• Analgesic Efficacy of Two Doses of Dexmedetomidine as Adjuncts to Lidocaine for Intravenous Regional Anesthesia
• The Use of Gastrografin to Help Alleviate Bowel Obstruction in Gastroschisis Patients.
• Effects of Bevespi on Ventilation and Gas Exchange Abnormalities in COPD Assessed by 129Xe MRI
• A Phase 1 Study of Intraoperative Administration of CA-008 for the Correction of Hallux Valgus Deformity
• Exploration of Anticoagulation Program in Cerebral Aneurysm and Arteriovenous Malformations With Hybrid Operation 2
• Efficacy of Intermittent Serial Casting on Spastic Wrist Flexion Deformity
• Efficacy of Rapamycin in the Treatment of Cervico-facial Lymphatic Malformations
• Effectiveness and Safety of Early Intramuscular Botulinum Toxin Injections to Prevent Shoulder Deformity in Babies With Obstetrical Brachial Plexus Palsy
• The Impact of N-Acetylcysteine on Volumetric Retention of Autologous Fat Graft for Breast Asymmetry Correction
• Amantadine Sulphate Usage in Spine Deformities Corrective Surgeries Patients
• Renal Anhydramnios Fetal Therapy
• Effect of Phosphodiesterase-5 Inhibition With Tadalafil on SystEmic Right VEntricular Size and Function
• The Protective Effect for Liver Organ in Patients With Anti-TB Drugs Using of Acetylcysteine (NAC)
• Electrosclerotherapy for Capillary Malformations
• An Efficacy and Safety Study of Niraparib in Men With Metastatic Castration-Resistant Prostate Cancer and DNA-Repair Anomalies
• Onreltea (Brimonidine) Gel In Pediatric Patients With Capillary Malformations
• Efficacy Study of Thalidomide in Gastrointestinal Vascular Malformation Related Bleeding
• Adjunctive Low-dose Metformin in Patients With Schizophrenia and Metabolic Abnormalities
• the Efficiency of Thalidomide for Recurrent Small Intestinal Bleeding Due to Gastrointestinal Vascular Malformation
• Efficacy and Safety of Sirolimus in Vascular Anomalies That Are Refractory to Standard Care
• Atorvastatin Treatment of Cavernous Angiomas With Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial
• Pilot Study of Efficacy of Nail Gel in Finger Nail Surface Abnormality
• Effect of Dexmedetomidine Combined With Sufentanil for Postoperative Intravenous Analgesia in Neurosurgery
• Efficacy of Acetaminophen in Posterior Fossa Surgery
• Use of the Cardioprotectant Dexrazoxane During Congenital Heart Surgery: Proposal for Pilot Investigation
• suPERficial Slow-flow Vascular malFORMations Treated With sirolimUS
• Clinical Translation of a Novel Albumin-Binding PET Radiotracer 68Ga-NEB
• Rejuvenated, Washed Packed Red Blood Cells in Pediatric Cardiac Surgery
• Using Ferumoxytol-Enhanced MRI to Measure Inflammation in Patients With Brain Tumors or Other Conditions of the CNS
• Efficacy of Octreotide on Blood and Iron Requirements in Patients With Anaemia Due to Angiodysplasias
• The Management of Systemic-Pulmonary Collateral Blood Flow in Cyanotic Children During Cardiopulmonary Bypass - Pilot Study
• Sildenafil for the Treatment of Lymphatic Malformations
• Bevacizumab Therapy for Brain Arteriovenous Malformation
• Retreatment and Its Efficiency of Thalidomide for Vascular Malformation Patients With Failure of First Course Treatment
• Long-term Safety, Curvature Deformity Characterization, and Immunogenicity Over Time in Subjects Previously Treated With AA4500 for Peyronies Disease
• Operative Treatment of Unstable Thoracic Cage Injuries and Chest Wall Deformity in Trauma
• Tranexamic Acid Effect on Platelet Aggregation Following Infant Cardiopulmonary Bypass
• Topical Tranexamic Acid in Major Paediatric Spine Deformity Surgery: A Randomized Controlled Trial
• Nplate® Pregnancy Exposure Registry
• Tranexamic Acid Dosing in Adult Spinal Deformity Surgery
• A Study of TAS-120 in Patients With Advanced Solid Tumors
• Prospective Evaluation of the Efficacy of Sirolimus (Rapamune®) in the Treatment of Severe Arteriovenous Malformations
• Antibiotic Prophylaxis and Renal Damage In Congenital Abnormalities of the Kidney and Urinary Tract
• Right Ventricular Dysfunction in Tetralogy of Fallot: Inhibition of the Renin-angiotensin-aldosterone System
• Human Craniomaxillofacial Allotransplantation
• Effect of Acetazolamide & Position in CSF Leakage and Collection and Wound Dehiscence
• Use of Spironolactone for the Prevention of Electrolyte Abnormalities in Patients Treated With Amphotericin B
• Efficacy and Safety of the Mammalian Target of Rapamycin (mTor Rapamycin) Inhibitor in Vascular Malformations
• Permeability MRI in Cerebral Cavernous Malformations Type 1 in New Mexico: Effects of Statins
• Cohort Prospective Study of Children With Head and Neck Cystic Malformation Who Are Treated With Intracystic OK432
• Epidural Analgesia and Troubles of Fetal Cardiaq Rythm : Effect of the Systemic Transfer of Ropivacaine and Sufentanil
• Bupropion & Cardio Birth Defect (Slone)
• Safety and Efficacy of TXA127 and Neupogen to Increase Peripheral Blood Stem Cells (PBSCs)
• A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)
• Compare Two Different Sclerosing Agents in the Treatment of Venous Malformations
• Study of Placebo or Bosentan to Treat Patients With Single Ventricle Physiology.
• A Study to Evaluate Sildenafil for the Treatment of Lymphatic Malformations
• Varenicline Pregnancy Cohort Study
• A Dose Escalation/Expansion Study of LDK378 in Patients With Tumors Characterized by Genetic Abnormalities in Anaplastic Lymphoma Kinase
• Folic Acid Dosage and Malformations Reduction
• Thymus Transplantation Safety-Efficacy
• Selenium in the Treatment of Complicated Lymphatic Malformations
• Involvement of Transverso-sacral- Neo- Articulations or of Transverso-iliac Articulations in Chronic Lumbago
• Bupropion and Specific Cardiovascular Malformations
• Antiretroviral Pregnancy Registry (APR)-Risk of Birth Defects
• Birth Defects Associated With Exposure to Lamotrigine in Pregnancy (EUROCAT)
• Safety and Efficacy Study of Sirolimus in Complicated Vascular Anomalies
• Study Using Citrate to Replace Heparin in Babies Requiring Extracorporeal Membrane Oxygenation (ECMO)
• Long-term Effects of Thalidomide for Recurrent Gastrointestinal Bleeding Due to Vascular Malformation
• Myocardial Protection With Adenosine Preconditioning
• Efficacy and Safety of Bevacizumab for the Treatment Hemorrhagic Hereditary Telangiectasia (HHT) Associated With Severe Hepatic Vascular Malformations. Phase II Study
• Long Term Safety of Clopidogrel in Neonates/Infants With Systemic to Pulmonary Artery Shunt Palliation
• Imaging Lymphatic Function in Normal Subjects and in Persons With Lymphatic Disorders
• The Impact of Treating Minor Uterine Cavity Abnormalities Diagnosed by Office Hysteroscopy in Unselected In Vitro Fertilization (IVF) Cases
• Influence of MMP on Brain AVM Hemorrhage
• PREDnisolone-induced Beta-cell Dysfunction Prevented by EXenatide
• Monitor the Incidence of Congenital Malformations in Infants of Women Who Have Been Treated With Ganirelix (Orgalutran®)(Study 38644)(P05966)(COMPLETED)
• An Open-label Extension Study to Assess the Long-term Safety and Efficacy of ISIS 301012 (Mipomersen) in Patients With Familial Hypercholesterolemia or Severe-Hypercholesterolemia
• Prenatal Steroids for Treatment of Congenital Cystic Adenomatoid Malformations (CCAM)
• Study to Assess the Safety and Efficacy of ISIS 301012 (Mipomersen) in Homozygous Familial Hypercholesterolemia
• Phase I/II Thymus Transplantation With Immunosuppression #950
• Effects of Perioperative Nesiritide or Milrinone Infusion on Recovery From Fontan Surgery
• Melatonin Metabolism Abnormality in Patients With Schizophrenia or Schizoaffective Disorder Treated With Olanzapine
• Open Label Extension of ISIS 301012 (Mipomersen) to Treat Familial Hypercholesterolemia
• Systemic and Local Diffusion of Ethanol After Administration of Ethanol 96% Formulated in a Gel and Ethanol 98% Solution by the Percutaneous Route, in Patients With Congenital Venous Malformations:Pharmacokinetic, Pharmacodynamic and Clinical Study.
• SPECS: Safe Pediatric Euglycemia in Cardiac Surgery
• Botox Injection for Lower Extremity Lengthening and Deformity Correction Surgery
• Effects of Methylphenidate on Cellular Abnormalities in Children With Attention Deficit Hyperactivity Disorder (ADHD)
• Efficacy And Safety Of Clopidogrel In Neonates /Infants With Systemic To Pulmonary Artery Shunt Palliation
• Thalidomide Reduces Arteriovenous Malformation Related Gastrointestinal Bleeding
• Measure Liver Fat Content After ISIS 301012 (Mipomersen) Administration
• Intravenous L-Citrulline to Treat Children Undergoing Heart Bypass Surgery
• Magnevist® Injection Enhanced MRA Compared to Non Contrast MRA for the Detection of Structural Abnormalities of the Aortic Arch and Cerebral Branches
• A Study to Evaluate Folate Levels in Women Taking Oral Contraceptives
• Effects of Additional Fentanyl to Epidural Bupivacaine for Post-Thoracotomy Pain in Neonates
• Nesiritide Use Following Cardiac Surgery in Infants
• Phase I Drug Trial for S/E of Marimastat in Disabling Malformations When no Other Options.
• Tetracycline-Derivatives for Treatment of Cerebral Arteriovenous Malformations and Aneurysms
• Citrulline for Children Undergoing Cardiopulmonary Bypass Surgery
• Hypertonic Saline Dextran in Pediatric Cardiac Surgery
• Pilot Study of Mycophenolate Mofetil in Congenital Uropathies
• Seronegatives and Metabolic Abnormalities Protocol 2 (SAMA002): Study to Compare the Effect of Kaletra and Combivir® in HIV-Negative Healthy Subjects
• Lenalidomide Versus Placebo in Myelodysplastic Syndromes With a Deletion 5q[31] Abnormality
• Angiotensin Converting Enzyme Inhibition in Children With Mitral Regurgitation
• Trial of Angiotensin Converting Enzyme Inhibition in Infants With Single Ventricle--Pediatric Heart Network
• Anakinra to Treat Patients With Neonatal Onset Multisystem Inflammatory Disease
• Study of Triostat in Infants During Heart Surgery
• Study of Picibanil (OK432) Sclerotherapy in Children With Macrocystic Lymphatic Malformations
• Liothyronine in Children With Single Ventricle Congenital Cardiac Malformations Undergoing the Fontan Procedure
• Study of the Relationship Between Calcium Levels and Intact Parathyroid Hormone (iPTH) in Adults With Repaired or Palliated Conotruncal Cardiac Defects
• Effect of Biosynthetic Growth Hormone and/or Ethinyl Estradiol on Adult Height in Patients With Turner Syndrome
• Management of Patent Ductus in Premature Infants