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Clinical Trials for Metabolic Diseases

• Effect of Krill Oil Supplementation on Red Blood Cell Physiology Against Changes in Markers of Iron Metabolism.
• Evaluating the Efficacy and Safety of Empagliflozin Addition to Insulin and Oral Antidiabetic Medication (OAD) Regimen in Poorly Controlled Type 2 Diabetes and Obese Patient
• ESG vs GLP-1RA vs ESG + GLP-1RA in Patients With Obesity, NAFLD and Advanced Fibrosis: A Randomized Controlled Trial
• Multidisciplinary Design to Optimize Schizophrenia Treatment Based on Multi-omics Data and Systems Biology Analysis
• Effects of Changing Intestinal Transit Time on Gut Microbial Composition and Metabolism
• Study to Evaluate the Efficacy and Safety of a Rilpivarine-based Antiretroviral Tratment Regimen in HIV- Infected Patients With Liver Metabolic Disease Who Maintain Udetectable HIV Viral Load
• Motor Function Efficacy of Pharmacological Treatments Targeting Energy Metabolism, in Parkinson's Patients
• Effects of GLP-1RA on Body Weight, Metabolism and Fat Distribution in Overweight/Obese Patients With Type 2 Diabetes Mellitus
• Effect of Dapagliflozin on Renal Outcomes and Bone Mineral Disease in Non-diabetic Chronic Kidney Disease Patients
• A Study of Tirzepatide (LY3298176) in Chinese Participants With Type 2 Diabetes
• Clinical Study to Evaluate Pharmacokinetic Profiles and Safety of CKD-387 Under Fasting Condition
• The RolE oF Androgen Excess in MUscle Energy MetaboLism in Women With PolyCystic Ovary Syndrome (REFUEL PCOS) Study 2
• The Efficacy and Safety of DWP16001 in Combination With Metformin in Patients With Type 2 Diabetes Inadequately Controlled on Metformin.
• Evaluation of Kisspeptin Stimulated Insulin Secretion With Hyperglycemic Clamp
• Quantifying Hepatic Mitochondrial Fluxes in Humans
• A Study to Evaluate Tirzepatide (LY3298176) in Pediatric and Adolescent Participants With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin or Basal Insulin or Both
• A Study of LY3561774 in Participants With Mixed Dyslipidemia
• Compare the Impact of Xuezhikang and Atorvastatin on Glucose Metabolism in Dyslipidemia Patients With Prediabetes
• Effects on Glucose Homeostasis of Changes in Plasma Lipoproteins Induced by Nutritional and Pharmacologic Strategies
• A Multi-cohort Study of Safety, Efficacy, PK and PD of GNR-055 in Patients With Mucopolysaccharidosis Type II
• To Evaluate the Safety of Treating Rheumatologic and Metabolic Patients With Molecular Hydrogen Supplement.
• A Study of Adeno-Associated Virus Serotype 8-Mediated Gene Transfer of Glucose-6-Phosphatase in Patients With Glycogen Storage Disease Type Ia (GSDIa)
• A Study of mRNA-3745 in Participants With Glycogen Storage Disease Type 1a (GSD1a)
• Different Initial Insulin Dose Regimens on Time to Achieve Glycemic Targets and Treatment Safety in SIIT
• Ameliorating Metabolic Profiling After Kidney Transplantation (AMPKT)
• Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Oral Glucose Tolerance Test
• Comparison of Atorvastatin and Pitavastatin on the Effect of HbA1c in AMI Patients With Abnormal Glucose Metabolism
• Comparison of Oral Semaglutide w/ Placebo- Treatment for Latino Adults w/T2 Diabetes Receiving Enhanced Lifestyle Care
• Dopaminergic Therapy for Frontotemporal Dementia Patients
• Efficacy and Safety of Dasiglucagon for Treatment of Post-bariatric Hypoglycemia in Roux-en-Y Gastric Bypass (RYGB) Operated Adults
• Doravirine Versus Integrase Inhibitors on Backbone of Emtricitabine and Tenofovir Alafenamide in HIV
• A Study of Two Doses of Dulaglutide (LY2189265) in Japanese Patients With Type 2 Diabetes
• A Clinical Trial to Evaluate the Bone Metabolism and the Blood Sugar of Evogliptin and Dapagliflozin
• Efficacy and Safety of EzetimiBe/Rosuvastatin in Diabetic Dislipidemia With Hypertriglyceridaemia
• Effect of Vitamin K Supplementation on Circulating Levels of Osteocalcin on the Bone Metabolism and Aging
• Xla1 Christensenella Minuta, Phase I, Randomized, Partially Placebo-controlled Double-blind Protocol, Evaluating Safety, Tolerability and Impact on the Gut Microbiota in Healthy Volunteers, Overweight and Obese Adults
• Effects of Glucose Lowering Agents in South Asian Women With Impaired Glucose Tolerance or Impaired Fasting Glucose
• A Clinical Trial to Evaluate the Preference Regarding Convenience of Medication and Efficacy/Safety of SUGAMET®XR Tablet 5/1000mg
• Cord Blood Transplant in Children and Young Adults With Blood Cancers and Non-malignant Disorders
• The Role of Secretin on the Energy Homeostasis
• Efficacy and Safety of Dipeptidyl Peptidase-4 Inhibitors in Diabetic Patients With Established COVID-19
• Phthalates Exposure in Type 2 Diabetic Patients and Diuretic Therapy
• IL-1-receptor Antagonist During Cephalic Phase of Insulin Secretion in Health and Type 2 Diabetes
• Can Levothyroxine Treatment Reduce the Development of Cardio-metabolic Disorder in Subclinical Hypothyroidism?
• A Study to Understand the Safety, Tolerability, and Activity of Drug in Body Over a Period of Time of AZD2693, in Subjects of Non-Childbearing Potential in Overweight But Otherwise Healthy Subjects, and Healthy Chinese and Japanese Subjects
• Dietary Fish Oil Intervention in Polycystic Ovary Syndrome (PCOS)
• NAUTICAL: Effect of Natriuretic Peptide Augmentation on Cardiometabolic Health in Black Individuals
• Hepcidin and Glucose Metabolism
• Metabolic Effects of Melatonin Treatment
• Subcutaneous Hydrocortisone Children With Congenital Adrenal Hyperplasia
• The Role of Hepatic Denervation in the Dysregulation of Glucose Metabolism in Liver Transplant Recipients
• Anaplerotic Therapy Using Triheptanoin for Patients With Glycogen Storage Disease Type I
• Metformin for Treatment of Psoriasis Combined With Disorders of Glucose and Lipid Metabolism
• A Single-arm Evaluation of the Effect of HCV Treatment on Cardiovascular Disease Risk
• Use of Functional MRI to Assess Functional Hypothalamic Activation in Response to Diazoxide
• Switch to Genvoya Followed by HCV Therapy With Epclusa Followed by Simplification of HIV Therapy With Biktarvy in Patients With HIV-HCV Co-Infected Subjects on Opioid Substitution Therapy
• Regulation of Endogenous Glucose Production by Central KATP Channels
• Soluble Epoxide Hydrolase Inhibition and Insulin Resistance
• To Determine the Effect of GLP1 on Cognitive Function, Brain Glucose Metabolism and Neuroplasticity.
• MGTA-456 in Patients With Inherited Metabolic Disorders Undergoing Hematopoietic Stem Cell Transplantation (HSCT)
• Study of ORL-1G (D-galactose) in Patients With Glycogen Storage Disease Type 14
• Safety, Tolerability and PK of PXL770 in Healthy Male Subjects
• Assess the Safety and Efficacy of Nephoxil® in Subjects With End Stage Renal Disease (ESRD) on Dialysis
• The Role of GLP-1 Receptor Signalling in the Glucose-lowering Effect of Metformin in Patients With T2D
• Delineation of the Role of Glucagon-like Peptide-1 Signalling in Relation to Increased Carbohydrate Content in the Distal Small Intestines
• Acute Metabolic Effects of Melatonin Treatment
• Vitamin D Supplementation on Metabolic Syndrome Indicators Among Older Adults, Alborz Province, Iran
• A Double Blind Randomised Placebo-controlled Trial to Assess the Role of Iron Repletion in Glucose Homeostasis.
• Diet Treatment Glucose Transporter Type 1 Deficiency (G1D)
• Reduced Intensity Conditioning and Familial HLA-Mismatched BMT for Non-Malignant Disorders
• Saline Lavage X Saline Lavage and Osteonil® Mini in Rizarthritis
• Fixed Combination for Lipid and Blood Pressure Control
• Treatment Development of Triheptanoin (G1D)
• Umbilical Cord Blood Transplantation From Unrelated Donors
• Dose-escalation Trial of the Safety, Pharmacokinetics, and Pharmacodynamics of Iron Isomaltoside (Monofer®)
• Effect of Vitamin D3 Supplementation on Arterial and Bone Remodeling in Chronic Kidney Disease Patients
• Triheptanoin in Mc Ardle
• Treatment of Wolfram Syndrome Type 2 With the Chelator Deferiprone and Incretin Based Therapy
• Lipolytic Effects of GH in Human Subjects in Vivo
• Lipolytic Effects of GH in Hypopituitary Patients in Vivo
• Safety and Exploratory Efficacy of HSC835 in Patients With Inherited Metabolic Disorders (IMD)
• Efficacy and Safety of Stannsoporfin in Neonates
• Comparison of Oral 30 % Dextrose and iv Midazolam Sedation During MRI in Neonates
• Compare Pharmacokinetic(PK) Profiles of XZK vs Lovastatin in Healthy Male Volunteers
• Related Hematopoietic Stem Cell Transplantation (HSCT) for Genetic Diseases of Blood Cells
• The Effect of Triheptanoin in Adults With McArdle Disease (Glycogen Storage Disease Type V)
• Lanthanum Versus Calcium Carbonate for Vascular Abnormalities in Patients With CKD and Hyperphosphatemia
• Comparing Soybean Oil-Based (Intralipid) With an Olive Oil-Based (ClinOleic) Lipid Emulsion on Healthy Volunteers
• MT2013-31: Allo HCT for Metabolic Disorders and Severe Osteopetrosis
• Effects of Colchicine in Non-Diabetic Adults With Metabolic Syndrome
• Study to Assess the Safety and Tolerability of Multiple Ascending Doses of REGN1500
• Comparison of A New Technique of Measure of the Insulin Resistance By Scintigraphy With the Reference Technique
• Phase 2 Clinical Trial of SGS-742 Therapy in Succinic Semialdehyde Dehydrogenase Deficiency
• Pilot Study To Assess CAT-2003 in Patients With Severe Hypertriglyceridemia
• Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT
• Effect of Pioglitazone Versus Metformin on Bone Health in Postmenopausal Women With Type 2 Diabetes
• Investigating Brown Adipose Tissue Activation in Humans
• Treatment of Iron Overload Requiring Chelation Therapy
• Impact of Blood Glucose at the First Trimester of Pregnant Women With Gestational Diabetes on Maternal and Fetal Outcomes and Metabolic Disorders: a Multi-central Prospective Cohort Study
• Multiple Dose Safety Toelrability, Pharmacokinetics and Midazolam Interaction In Healthy Overweight And Obese Subjects
• Somatostatin Analogue Treatment of Acromegaly: Molecular Aspects
• T-IR- Study to Understand the Effects of Testosterone and Estrogen on the Body's Response to the Hormone Insulin
• Influence of Caloric Restriction and Resveratrol in the Sirtuin System in Women and Men Aged 55 to 65 Years
• EPI-743 for Metabolism or Mitochondrial Disorders
• Effect of Caloric Restriction on Fat Oxidation in Obese Men and Women (Magellan II)
• Pilot Trial of Clofarabine Added to Standard Busulfan and Fludarabine for Conditioning Prior to Allogeneic Hematopoietic Cell Transplantation
• Evaluation of the Safety and Efficacy of TXA127 (Angiotensin 1-7) to Enhance Engraftment in Pediatric Patients Undergoing Single or Double Umbilical Cord Blood Transplantation
• Efficacy and Safety of Fluvastatin Sodium Extended Release Tablets 80 mg Once Daily in Chinese Patients With Primary Hypercholesterolemia or Mixed Dyslipidemia
• The Effect of Fibrate Therapy in Two Patients With Neutral Lipid Storage Disease With Myopathy (NLSDM)
• Comparative Bioavailability - Gender Effect - Single and Multiple Ascending Dose Safety and Pharmacokinetic Study of GFT505
• Characterisation of the Human Carboxylesterase 1 (CES1) Mutations in Thailand
• A Single Dose Study In Japanese And Western Healthy Subjects To Investigate The Safety, Tolerability And Pharmacokinetics Of PF-04991532
• Adverse Events in Pharmaceutical Bioequivalence Study of Two Formulations of Metformine Hydrochloride 500 mg
• Hepatocyte Transplantation for Liver Based Metabolic Disorders
• Trial of Two Central Venous Catheter (CVC) Flushing Schemes in Pediatric Hematology and Oncology Patients
• Effects of IGF-I in HIV Metabolic Disease
• Effect of Taurine on Glycemic Control in Type I and Type II Diabetic Patients
• The Effect of Proton Pump Inhibitors on Calcium and Bone Metabolism
• Multiple Dose Study of PF-04991532 in Patients With Type 2 Diabetes
• Aldosterone and the Metabolic Syndrome
• Single Dose Study of PF-04991532 in Healthy Subjects
• Allogeneic Bone Marrow Transplant for Inherited Metabolic Disorders
• A Study of the Safety of R256918 in Obese Patients
• Central Mechanisms That Regulate Glucose Metabolism in Humans
• Effect of Fish Oil (Omega-3 Fatty Acids) on Arteries
• Campath/Fludarabine/Melphalan Transplant Conditioning for Non-Malignant Diseases
• Safety and Efficacy Study of ISIS 301012 (Mipomersen) Administration in High Risk Statin Intolerant Subjects
• An Open-label Extension Study to Assess the Long-term Safety and Efficacy of ISIS 301012 (Mipomersen) in Patients With Familial Hypercholesterolemia or Severe-Hypercholesterolemia
• Effects of Intravenous Injection of Erythropoietin on Hepcidin Pharmacokinetics in Healthy Volunteers
• A Study of the Safety and Effectiveness of a R256918 in Patients With Type 2 Diabetes
• Efficacy of Pamidronate in the Treatment of Bone Loss Associated With Liver Transplant
• Open Label Study Evaluating The Use Of Combination Therapy Of Ezetimibe And Statins In Patients With Dyslipidemia In Colombia (0653-141)(COMPLETED)
• A Study of the Safety and Effectiveness of JNJ-16269110 (R256918) in Overweight and Obese Patients
• Study to Assess the Safety and Efficacy of ISIS 301012 (Mipomersen) in Homozygous Familial Hypercholesterolemia
• A 52 Week Study to Evaluate the Effects of Losartan With or Without HCTZ on Plasma Glucose, Metabolic Parameters, Blood Pressure in Hypertensive Patients With Metabolic Syndrome (0954A-331)
• One Year Glargine Treatment in CFRD Children and Adolescents
• Open Label Extension of ISIS 301012 (Mipomersen) to Treat Familial Hypercholesterolemia
• Pilot Study of a Multi-Drug Regimen for Severe Pulmonary Fibrosis in Hermansky-Pudlak Syndrome
• Islet Allotransplantation With Steroid Free Immunosuppression
• Effect of an Anti-Oxidant Treatment on Resistin Serum Levels.A Randomized Study
• Fenofibrate and Metformin Fixed Combination vs Metformin - FAME METFO
• Measure Liver Fat Content After ISIS 301012 (Mipomersen) Administration
• Fenofibrate and Metformin Fixed Combination vs Rosiglitazone - FAME ROSI
• The Effects of Potassium Citrate on Bone Metabolism
• Fenofibrate in Dyslipidemia and Metformin-Controlled Diabetes
• Acceptability of a Fixed Combination of Fenofibrate and Metformin
• Pioglitazone in Impaired Glucose Tolerance
• Rasburicase for Hyperuricemia
• Acarbose and Secondary Prevention After Coronary Stenting
• Seronegatives and Metabolic Abnormalities Protocol 2 (SAMA002): Study to Compare the Effect of Kaletra and Combivir® in HIV-Negative Healthy Subjects
• Study of Alendronate to Prevent and Treat Osteoporosis in Cystic Fibrosis Patients
• Education, Counseling, and Drug Therapy to Reduce Symptoms of Metabolic Syndrome
• Chromium Picolinate for the Treatment of Metabolic Syndrome
• Effectiveness of Nucleoside Supplementation or Switch to Tenofovir in Reversing Fat Loss in HIV Infected Adults
• The Effect of Hypocol® on Lipids in Subjects With Mild Hypercholesterolemia and Mildly Elevated Blood Glucose
• Effects of Insulin Sensitizers in Subjects With Impaired Glucose Tolerance
• The DREAM (Diabetes Reduction Assessment With Ramipril and Rosiglitazone Medication) Trial
• Monoclonal Antibody Conditioning for Allogeneic Stem Cell Transplantation of Patients With Inherited Metabolic Storage Diseases
• A Study of the Safety and Pharmacokinetics of rhGAA in Siblings With Glycogen Storage Disease Type II
• Safety and Efficacy of Xenical in Children and Adolescents With Obesity-Related Diseases
• Metabolic Abnormalities in Children With Epilepsy