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Clinical Trials for Respiratory Insufficiency

• ENA-001 for Post Operative Respiratory Depression (PORD)
• Weaning Protocol for High-flow Nasal Oxygen Therapy in Intensive Care
• Optimization of Sedation Protocol for Endoscopic Procedures Using Impedance Ventilation Monitor.
• Influence of Oxycodone on Individuals Taking an SSRI
• Sivelestat for Acute Respiratory Distress Syndrome Due to COVID-19
• Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
• Combined Effect of Pregabalin and Oxycodone, and Lacosamide and Oxycodone, on Breathing
• Neural Pressure Support for Low Pulmonary Compliance
• Viscoelastic Testing Guided Tissue Plasminogen Activator Treatment in Acute Respiratory Failure
• the Inhaled β2-adrenergic Receptor Agonist for Transient Tachypnoea of the Newborn (the REFSAL Trial)
• Effect of Selective Serotonin Reuptake Inhibitors (SSRIs) and an Opioid on Ventilation
• Oliceridine in Patients With Acute Burn Injuries
• Cuff Leak Test and Airway Obstruction in Mechanically Ventilated ICU Patients
• Effect of Sedation Strategy on Duration Mechanical Ventilation in Patient After Cardiac Surgery
• Platform of Randomized Adaptive Clinical Trials in Critical Illness
• Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age
• Using Vasopressor Medication to Support Blood Pressure During Intubation Procedure
• Reversal of Opioid-induced Respiratory Depression With Opioid Antagonists
• Bivalirudin Versus Enoxaparin in Critically Ill COVID-19 Patients
• High-dose L-Carnitine and Diaphragmatic Function Assessed by Ultrasonography in Patients With Respiratory Failure.
• Combination of Inhaled DNase, Baricitinib and Tocilizumab in Severe COVID-19
• Randomized Trial of Sedative Choice for Intubation
• Influence of Δ9-tetrahydrocannabinol (THC) on Oxycodone Induced Ventilatory Depression in Healthy Volunteers
• Normal Saline Nebulization on Prevention of Extubation Failure in Neonates
• Propofol Versus Esketamine for Rapid Sequence Intubation in Critically Ill Patients
• Azithromycin Treatment for Respiratory Syncytial Virus-induced Respiratory Failure in Children
• Effect of Different Sedation and Analgesia Strategies on Patients With Mechanical Ventilation
• Preventing Cardiovascular Collapse With Vasopressors During Tracheal Intubation
• Protective Effect of Sivelestat Sodium on ARDS in Patients With Sepsis Complicated With Respiratory Failure
• Safety and Efficacy of Argatroban Applicated in Anticoagulation of V-V ECMO
• Pectointercostal Fascial Plane Block (PIFB) Alone Versus PIFB With Serratus Anterior Plane Block (SAPB) in Cardiac Surgery
• Non-invasive Ventilation and Dex in Critically Ill Adults
• Nebulized Heparin for COVID19-associated Acute Respiratory Failure
• Low or High Dose of Dexamethasone in Patients With Respiratory Failure by COVID-19
• Ganciclovir to Prevent Reactivation of Cytomegalovirus in Patients With Acute Respiratory Failure and Sepsis
• Study to Evaluate the Safety, Tolerability, and Efficacy of BGE-175 in Hospitalized Adults With Coronavirus Disease 2019 (COVID-19) That Are Not in Respiratory Failure
• Treatment of CRF With Syndrome Differentiation of TCM
• suPAR-Guided Anakinra Treatment for Management of Severe Respiratory Failure by COVID-19
• Empirical Steroids and/or Antifungals in Immunocompromised Patients With Acute Respiratory Failure From Undetermined Etiology: a Multicenter Double-blind Randomized Controlled Trial
• A Study to Evaluate Clazakizumab in Patients With Life-threatening COVID-19 Infection
• Use of Angiotensin-(1-7) in COVID-19
• REmimazolam Infusion in the Context of Hypnotic Shortage in the Critical Care Unit During the Pandemic of COVID-19: REHSCU Study
• Senicapoc in COVID-19 Patients With Severe Respiratory Insufficiency
• Furosemide as Supportive Therapy for COVID-19 Respiratory Failure
• A Study of RLS-0071 in Patients With Acute Lung Injury Due to COVID-19 Pneumonia in Early Respiratory Failure
• Intravenous L-Citrulline to Delay and Potentially Prevent the Need for Invasive Mechanical Ventilation for Acute Hypoxemic Respiratory Failure in Patients With COVID-19 (SARS-CoV-2) Illness
• Effect of Arterio-venous ECMO on Severe Sepsis and ARDS
• Nebulised Heparin in Patients With Severe COVID-19
• Efficacy of DEXamethasone in Patients With Acute Hypoxemic REspiratory Failure Caused by INfEctions
• Aerosoliserat DNase for Treatment of Respiratory Failure in Severe COVID-19
• Reduced Anticoagulation Targets in ECLS (RATE)
• Evaluation of the Efficacy and Safety of Treatments for Patients Hospitalized for COVID-19 Infection Without Signs of Acute Respiratory Failure, in Tunisia
• Partial Neuromuscular Blockade in Acute Respiratory Distress Syndrome
• Telmisartan in Respiratory Failure Due to COVID-19
• Tenecteplase in Patients With COVID-19
• Veno-venous Extracorporeal Membrane Oxygenation (VV-ECMO) Heparin Study
• Mavrilimumab to Reduce Progression of Acute Respiratory Failure in COVID-19 Pneumonia and Systemic Hyper-inflation
• Effects of mTOR Inhibition With Sirolimus (RAPA) in Patients With COVID-19 to Moderate the Progression of ARDS
• To Determine the Efficacy of Neurokinin 1 Receptor Antagonist as a Therapeutic Tool Against Cytokine Storm and Respiratory Failure in Covid-19 Patients
• Mavrilimumab to Reduce Progression of Acute Respiratory Failure in COVID-19 Pneumonia and Systemic Hyper-inflammation
• Phase 2 Trial Using rhDNase to Reduce Mortality in COVID-19 Patients With Respiratory Failure
• Inhaled Iloprost for Suspected COVID-19 Respiratory Failure
• Pemziviptadil (PB1046), a Long-acting, Sustained Release Human VIP Analogue, Intended to Provide Clinical Improvement to Hospitalized COVID-19 Patients at High Risk for Rapid Clinical Deterioration and Acute Respiratory Distress Syndrome (ARDS).
• Doxapram Therapy in Preterm Infants (DOXA Trial)
• Standard or Convalescent Plasma in Patients With Recent Onset of COVID-19 Respiratory Failure
• Handling Oxygenation Targets in COVID-19
• Infusion of Prostacyclin (Iloprost) vs Placebo for 72-hours in COVID-19 Patients With Respiratory Failure
• SedAting With Volatile Anesthetics Critically Ill COVID-19 Patients in ICU: Effects On Ventilatory Parameters And Survival
• NORMAL HUMAN IMMUNOGLOBULINS (IVIG) IN PATIENTS AGED 75 YEARS AND OVER, COVID-19 WITH SEVERE ACUTE RESPIRATORY FAILURE
• Treatment of Lung Injury From COVID-19 Infection With Intravenous Sodium Nitrite
• Mavrilimumab to Reduce Progression of Acute Respiratory Failure in COVID-19 Pneumonia and Systemic Hyper-inflammation
• iNOPulse for COVID-19
• Mavrilimumab in Severe COVID-19 Pneumonia and Hyper-inflammation (COMBAT-19)
• ABX464 in Treating Inflammation and Preventing Acute Respiratory Failure in Patients With COVID-19
• Dociparstat for the Treatment of Severe COVID-19 in Adults at High Risk of Respiratory Failure
• Zilucoplan® in Improving Oxygenation and Short- and Long-term Outcome of COVID-19 Patients With Acute Hypoxic Respiratory Failure
• Study of Efficacy and Safety of MAS825 in Patients With COVID-19
• Study of Efficacy and Safety of DV890 in Patients With COVID-19 Pneumonia
• Tocilizumab for Prevention of Respiratory Failure in Patients With Severe COVID-19 Infection
• Study of Oral Ibrutinib Capsules to Assess Respiratory Failure in Adult Participants With Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and Pulmonary Injury
• Enhanced Platelet Inhibition in Critically Ill Patients With COVID-19
• Low Dose Morphine to Relieve Dyspnea in Acute Respiratory Failure (OPIDYS)
• Fibrinolytic Therapy to Treat ARDS in the Setting of COVID-19 Infection
• Efficacy of Intravenous Almitrine in Reducing the Need for Mechanical Ventilation in Patients With Hypoxemic Acute Respiratory Failure Due to Covid-19-related Pneumonia
• suPAR-guided Anakinra Treatment for Validation of the Risk and Management of Respiratory Failure by COVID-19 (SAVE)
• Dapagliflozin in Respiratory Failure in Patients With COVID-19
• Use of Dexmedetomidine in Light to Moderate Sedation in the Patient in the Palliative Situation of a Sars-cov-2 / COVID-19 Infection
• Study of Ruxolitinib Plus Simvastatin in the Prevention and Treatment of Respiratory Failure of COVID-19.
• A Study of the Effectiveness of an Off Label Mefloquine Use for the Treatment of Patients With COVID19
• Dexamethasone and Oxygen Support Strategies in ICU Patients With Covid-19 Pneumonia
• Azithromycin Added to Hydrochloroquine in Patients Admitted to Intensive Care With COVID-19: Randomised Controlled Trial
• Mavrilimumab to Reduce Progression of Acute Respiratory Failure in Patients With Severe COVID-19 Pneumonia and Systemic Hyper-inflammation
• Defibrotide in COVID-19 Pneumonia
• Angiotensin-(1,7) Treatment in COVID-19: the ATCO Trial
• Safety and Efficacy of Hyperbaric Oxygen for ARDS in Patients With COVID-19
• Sargramostim in Patients With Acute Hypoxic Respiratory Failure Due to COVID-19 (SARPAC)
• Revefenacin in Acute Respiratory Insufficiency in COPD
• Intravenous Aviptadil for Critical COVID-19 With Respiratory Failure
• Clinical Study to Investigate the Effect of the Combination of Psychotropic Drugs and an Opioid on Ventilation
• Pupillary Unrest in Ambient Light, and Relationship to Opioid-Induced Respiratory Depression
• Acetaminophen and Ascorbate in Sepsis: Targeted Therapy to Enhance Recovery
• Anticoagulation-free VV ECMO for Acute Respiratory Failure
• Yiqi Huoxue Huatan Granule for Reducing Mortality in COPD With Chronic Respiratory Failure
• Totally Transdermal Sedation in the Weaning From Remifentanil Infusion
• ARrest RESpiraTory Failure From PNEUMONIA
• Rapid Atrial Fibrillation Treatment Strategy
• Vital Signs-Integrated Patient-Assisted Intravenous Opioid Analgesia for Post Surgical Pain
• Single Dose Crossover Study to Compare the Respiratory Drive After Administration of Belbuca, Oxycodone and Placebo.
• Phrenic Nerve Block to Mitigate Self-inflicted Lung Injury
• Avoiding Neuromuscular Blockers to Reduce Complications
• Effect of Opioids on Ventilation in Children With Obstructive Sleep Apnea
• Preventing Cardiovascular Collapse With Administration of Fluid Resuscitation During Induction and Intubation
• RIB PAIN (Rib Fractures Treated With Parental Analgesia With Infused LidocaiNe)
• Partial Neuromuscular Blockade for Lung Protective Mechanical Ventilation
• Pan-genotypic Direct Acting Antiviral Therapy in Donor HCV-positive to Recipient HCV-negative Lung Transplant
• Change of Lung Function After Exercise in Patients With Chronic Obstructive Pulmonary Disease
• REgistry-based Treatment Duration and Mortality in Long-term OXygen Therapy (REDOX)
• Sedation and Ease of Weaning From Mechanical Ventilation
• The Study of Pharmacokinetics and Pharmacodynamics of Cisatracurium
• Targeted OXYgen Therapy in Critical Illness
• TC02 Obese Women Using It Morphine vs PCA IV Hydromorphone for Post-Cesarean Analgesia
• Handling Oxygenation Targets in the Intensive Care Unit
• Incidence Of Hemidiaphragmatic Paralysis After Usg Guided Low Dose Interscalene Brachial Plexus Block
• Preventing Cardiovascular collaPse With Administration of Fluid Resuscitation Before Endotracheal Intubation
• Nutrition and Exercise in Critical Illness
• Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing Tonsillectomy
• Fixed Low-dose Heparin Versus Standard Adjusted-dose Heparin Infusion in Adults Receiving Venovenous ECMO With a Heparin Bonded Circuit.
• Dexmedetomidine Versus Standard Clinical Practice During Non Invasive Mechanical Ventilation
• Milrinone in Congenital Diaphragmatic Hernia
• Abnormal Ventilatory Response to Carbon Dioxide: a Potential Biomarker for Seizure Induced Respiratory Depression & Modification by SSRI
• The Use of Low Dose Prophylactic Naloxone Infusion to Prevent Respiratory Depression With Intrathecal Morphine.
• Effect of Neuromuscular Blockade and Reversal on Breathing
• Sugammadex vs Placebo to Prevent Residual Neuromuscular Block
• Respiratory Depression in Women With BMI≥30 Underwent Spinal Anesthesia With Intrathecal Morphine in Elective C-section
• Self-management of Sedative Therapy by Ventilated Patients
• Vital-signs-integrated Patient-assisted Intravenous Opioid Analgesia
• Antagonism of Opioid-Induced Respiratory Depression by CX1739 With Preservation of Opioid Analgesia
• Prospective Pilot Clinical Trial of Azithromycin Treatment In Respiratory Syncytial Virus (RSV)- Induced Respiratory Failure In Children
• Predictors of Opioid-Induced Respiratory Depression (OIRD)
• Non-invasive Ventilation in Reducing the Need for Intubation in Patients With Cancer and Respiratory Failure
• Diclofenac Premedication, as the Effect of Preemptive Analgesia After Post-thoracotomy Chest and Shoulder Pain
• Oxygen Therapy During Acute Respiratory Failure in Immuno-compromised Patients
• Intra-operative Inspiratory Oxygen Fraction and Postoperative Respiratory Complications
• Sedation During Noninvasive Ventilation (NIV)
• Pilot Study on Pairing Sedation Strategies and Weaning
• Noninvasive Ventilation Bundle in Postoperative Respiratory Failure
• Study of Sedative Medications in Patients With Severe Infection and Respiratory Failure
• Effectiveness of Routine Nebulization of Mucolytics and Bronchodilators During Mechanical Ventilation
• A Study of Rivaroxaban (JNJ-39039039) on the Venous Thromboembolic Risk in Post-Hospital Discharge Patients
• Modafinil Versus Placebo for Hypoactive Delirium in the Critically Ill
• The Effect of Thiamine vs. Placebo on VO2 in Critical Illness
• The Effects of Ketamine on Respiratory Stimulation and Transpulmonary Pressures
• Beta Agonist Nebulization in Non Invasively Ventilated COPD Patients: Safety, and Therapeutic Efficacy Range.
• Nebulized Hypertonic Saline for Mechanically Ventilated Children
• Brain Oxygenation and Function of Preterm Newborns During Administration of Two Different Surfactant Preparations
• Pharmacokinetic Alterations During ECMO
• Supplemental Parenteral Nutrition in Pediatric Respiratory Failure
• Prehospital Ventilator-Associated Pneumonia Prevention Trial
• Early iNO for Oxidative Stress, Vascular Tone and Inflammation in Babies With Hypoxic Respiratory Failure
• Reduction of Bacterial Resistance With Inhaled Antibiotics in the Intensive Care Unit
• Study of Respiratory Depression When Using a Hydromorphone Pain Protocol
• Caffeine to Reduce Mechanical Ventilation in Preterm Infants
• Effect of Interscalene Block on Ventilatory Function
• A Study To Evaluate Safety And Efficacy Of IV Sildenafil In The Treatment Of Neonates With Persistent Pulmonary Hypertension Of The Newborn
• Effect of Intraperitoneal and Intravenous Lignocaine on Pain Relief Following Laparoscopic Cholecystectomy
• Heparin Binding Protein in Patients With Acute Respiratory Failure Treated With GCSF (Filgrastim)
• Safety Study of Nebulized Sodium Nitroprusside in Adult Acute Lung Injury
• Stop Hypernatremia, Use Metolazone, for Aggressive, Controlled, Effective Diuresis
• Testing the Feasibility of Patient Controlled Sedation for Ventilated ICU Patients
• Comparison of Morphine and Fentanyl/Midazolam in Intensive Care Unit
• Heart And Lung Failure - Pediatric INsulin Titration Trial
• Physiological Response to Heliox21 and Air O2
• Inhaled Prostaglandin E1 (IPGE1) for Hypoxemic Respiratory Failure (NHRF)
• Effect of Thiamine on Oxygen Utilization (VO2) in Critical Illness
• Study of Sildenafil to Treat Newborns With Persistent Pulmonary Hypertension
• Ganciclovir/Valganciclovir for Prevention of CMV Reactivation in Acute Injury of the Lung and Respiratory Failure
• Cycling of Sedative Infusions in Critically Ill Pediatric Patients
• Dexmedetomidine in Mechanically Ventilated Neonates With Single-Organ Respiratory Failure.
• Trial of Supplemental Parenteral Nutrition in Under and Over Weight Critically Ill Patients (TOP-UP)
• Donor Simvastatin Treatment in Organ Transplantation
• Hydromorphone Pharmacokinetic-Pharmacodynamic Fingerprint
• Dexmedetomidine Pharmacokinetics-pharmacodynamics in Mechanically Ventilated Children With Single-organ Respiratory Failure
• Study To Investigate Safety And Efficacy Of Sildenafil In The Newborns With Persistent Pulmonary Hypertension (PPHN)
• Inhaled Iloprost as an Adjunct to Inhaled Nitric Oxide in Pediatric Critical Care Patients
• Study Using Citrate to Replace Heparin in Babies Requiring Extracorporeal Membrane Oxygenation (ECMO)
• Inhaled Nitric Oxide (INO) In Hypoxic Respiratory Failure
• Efficacy and Safety of Dexmedetomidine During Non-Invasive Positive Pressure Ventilation
• How Your Patients' Non-REM Sleep Changes On Sedatives in the Intensive Care Units
• Broncho-alveolar Lavage Under Noninvasive Ventilation With Propofol TCI in Patient With AHRF
• Inhaled Nitric Oxide by Oxygen Hood in Neonates
• Comparison of the Efficacy for Stress Ulcer Prophylaxis Between the Patients Received Lansoprazole OD and Control Group Weaning From Mechanical Ventilator in Respiratory Care Center: a Randomized Control Trial
• Long-term Extension Study of BEMA™ Fentanyl
• Effects of Remifentanil on Respiratory Function in Mechanically Ventilated Patients
• Efficacy and Safety of Resatorvid in Patients With Sepsis-induced Cardiovascular and Respiratory Failure
• Non-Invasive Mechanical Ventilation in Elderly Patients
• Inhaled PGE1 in Neonatal Hypoxemic Respiratory Failure
• Lucinactant for Treatment of Acute Hypoxemic Respiratory Failure in Children up to Two Years Old
• Controlled Study of ONO-5046Na in Patients With Acute Respiratory Failure Associated With Community-Acquired Pneumonia
• Dexmedetomidine for the Control of Post-Operative Pain in Thoracotomy Patients
• Immunonutrition and Thoracoabdominal Aorta Aneurysm Repair
• Enteral Glutamine in Critical Illness
• Treatment of Survivors After Botulism Outbreak
• The Effect of Intensive Insulin Therapy in the Surgical Critical Care Unit
• Effectiveness and Safety Study of Etomidate Versus Midazolam to Help Place a Breathing Tube Outside of the Hospital.
• IRAD2 : Patients With Respiratory Failure at Home
• Acetazolamide for Respiratory Failure in Combination With Metabolic Alkalosis
• Sedation in the Intensive Care Unit
• Ketamine Sedation in Mechanically Ventilated Patients
• Loxapine and Weaning From Ventilator
• Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics
• Inhaled Nitric Oxide for Preterm Infants With Severe Respiratory Failure
• Inhaled Nitric Oxide Study for Respiratory Failure in Newborns
• Early Surfactant to Reduce Use of Mechanical Breathing in Low Birth Weight Infants
• Early Inhaled Nitric Oxide for Respiratory Failure in Newborns